Publication Name	World Journal of Gastroenterology
Manuscript ID	71286
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum
Manuscript Source	Unsolicited Manuscript
All Author List	Qiao-Li Jiang, You Lu, Meng-Jie Zhang, Zhen-Yu Cui, Zhong-Mei Pei, Wen-Hua Li, Lun-Gen Lu, Jing-Jing Wang and Ying-Ying Lu
Funding Agency and Grant Number	Funding Agency Grant Number The Science and Technology Projects of Shanghai Jiangqiao Hospital 202134A The Science and Technology Projects of Shanghai Jiangqiao Hospital 202125A
Corresponding Author	Ying-Ying Lu, PhD, Associate Chief Physician, Department of Gastroenterology, Shanghai general Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Songjiang Road, Shanghai 201620, China. le_voyageur@qq.com
Key Words	Hyperplasia; Bacteroides; Small intestine; Microbiome; Helicobacter pylori; Colonoscopy
Core Tip	Nodular lymphoid hyperplasia (NLH) in the small intestine is a rare benign lesion characterized by multiple small nodules on the surface of the intestine. To explore the correlation between the intestinal flora and terminal ileal NLH, we performed bacterial 16S rRNA gene sequencing of mucosal samples from patients with terminal ileal NLH. Our results reveal that specific microflora may act on the mucosa of the small intestine and cause terminal ileal NLH. Therefore, maintaining the balance of intestinal flora and supplementing targeted protective bacteria may improve terminal ileal NLH symptoms and potentially reduce the risk of lymphoma transformation.
Citation	Jiang Q, Lu Y, Zhang M, Cui Z, Pei Z, Li W, Lu L, Wang J, Lu Y. Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum. World J Gastroenterol 2022; 28(8): 811-824

Received	2021-10-01 00:41
Peer-Review Started	2021-10-01 00:43
To Make the First Decision
Return for Revision	2021-11-07 05:26
Revised	2021-11-19 14:51
Second Decision	2022-01-13 05:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-14 06:18
Articles in Press	2022-01-14 06:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-16 09:26

ISSN	1007-9327 (print) and 2219-2840 (online)
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