Publication Name	World Journal of Gastroenterology
Manuscript ID	71745
Country	Serbia

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Interplay between chronic hepatitis B and atherosclerosis: Innovative perspectives and theories
Manuscript Source	Invited Manuscript
All Author List	Ivan Ranković, Vladimir Milivojević, Aleksandra Pavlović Marković and Mihailo Bezmarević
Funding Agency and Grant Number
Corresponding Author	Mihailo Bezmarević, MD, MSc, Doctor, Senior Researcher, Surgical Oncologist, Department of Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military Medical Academy, University of Defense, Crnotravska 17, Belgrade 11000, Serbia. bezmarevicm@gmail.com
Key Words	Hepatitis B virus infection; Carotid atherosclerosis; Hepatitis B e antigen; Arterial inflammation; Perspectives and trends
Core Tip	Hepatitis B virus (HBV) infection is a multifaceted disease, with significant cardiovascular morbidity. Our innovative approach to this pathophysiologic relationship harbors several key ideas. First, HBV infection may carry a specific atherosclerosis distribution pattern, with predilection for carotid arteries. Second, we propose wider use of more sensitive inflammatory markers, such as high-sensitivity C-reactive protein and homocysteine. Third, macrophage phenotype function should be investigated, utilizing its potential role as an atherosclerosis biomarker in HBV infection and therapeutic target. Last but not least, we reason that statins should be exploited more in current practice, due to their favorable pleotropic effects.
Citation	Ranković I, Milivojević V, Pavlović Marković A, Bezmarević M. Interplay between chronic hepatitis B and atherosclerosis: Innovative perspectives and theories. World J Gastroenterol 2022; 28(4): 497-499

Received	2021-09-20 08:56
Peer-Review Started	2021-09-20 08:58
To Make the First Decision
Return for Revision	2021-11-07 06:43
Revised	2021-11-17 16:04
Second Decision	2022-01-13 05:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-14 06:18
Articles in Press	2022-01-14 06:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-18 03:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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