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6/26/2022 11:58:29 PM | Browse: 36 | Download: 63
Publication Name World Journal of Diabetes
Manuscript ID 72326
Country/Territory China
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice
Manuscript Source Unsolicited Manuscript
All Author List Hong-Qin Li, Nian Liu, Zong-Yu Zheng, Hao-Lin Teng and Jin Pei
Funding Agency and Grant Number
Corresponding Author Jin Pei, PhD, Professor, Department of Biopharmacy, Jilin University School of Pharmaceutical Sciences, No. 1163, Xinmin street, Changchun 130021, Jilin Province, China. peijin@jlu.edu.cn
Key Words Diabetes; Clopidogrel; Inflammation; Fibronectin; Diabetic nephropathy
Core Tip Diabetic nephropathy is the most common microvascular inflammatory disease among the diabetic complications. Previous studies have shown that clopidogrel administration is an effective means of suppressing inflammation in diseases such as acute myocardial infarction, diabetes, and acute ischemic cerebral infarction. In this study, we aimed to determine whether treatment with clopidogrel has a preventive or therapeutic effect in the kidneys of obese, type 2 diabetic db/db mice. In this experiment, we demonstrated that clopidogrel significantly reduced renal collagen deposition and fibrosis and prevented renal dysfunction in db/db mice, most likely through inhibition of renal macrophage infiltration and the associated inflammation.
Citation Li HQ, Liu N, Zheng ZY, Teng HL, Pei J. Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice. World J Diabetes 2022; 13(8): 600-612
Received
2021-10-18 07:13
Peer-Review Started
2021-10-18 07:15
To Make the First Decision
Return for Revision
2021-12-27 07:06
Revised
2022-01-26 00:11
Second Decision
2022-06-22 09:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-26 23:58
Articles in Press
2022-06-26 23:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-07 14:14
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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