Publication Name	World Journal of Psychiatry
Manuscript ID	74300
Country	China

Category	Clinical Neurology
Manuscript Type	Observational Study
Article Title	Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population
Manuscript Source	Invited Manuscript
All Author List	Ying Li, Jun-Juan Yan and Yong-Hua Cui
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82171538 Beijing Natural Science Foundation 7212035
Corresponding Author	Yong-Hua Cui, MD, Chief Doctor, Department of Psychiatry, Beijing Children's Hospital, No. 56 Nanlishi Road, Beijing 100045, China. cuiyonghua@bch.com.cn
Key Words	Treatment-refractory Tourette syndrome; Yale Global Tic Severity Scale; Child Behavior Checklist; Premonitory Urge for Tics Scale; Social withdrawal; Obsessive-compulsive disorder
Core Tip	This study provides important evidence of treatment-refractory Tourette syndrome (TS) among Chinese patients due to the current shortage of studies based on Chinese samples. We found that the onset age of pediatric patients with treatment-refractory TS (TRTS) might be younger, and they might have a longer duration of illness, a lower intelligence quotient, and a higher premonitory urge, which often fluctuate due to psychosocial factors. Moreover, TRTS children might suffer more emotional and behavioral problems including social communication deficits (such as uncommunicative and social withdrawal), attention deficit hyperactivity disorder-related symptoms (hyperactive, aggressive, and delinquent), and obsessive-compulsive symptoms. These were the basic clinical characteristics of TRTS based on Chinese pediatric patients. Unravelling these clinical characteristics is beneficial for the early diagnosis and treatment of TRTS.
Citation	Li Y, Yan JJ, Cui YH. Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population. World J Psychiatry 2022; 12(7): 958-969

Received	2021-12-21 04:49
Peer-Review Started	2021-12-21 04:50
To Make the First Decision
Return for Revision	2022-03-13 21:42
Revised	2022-04-06 01:48
Second Decision	2022-06-21 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-27 01:38
Articles in Press	2022-06-27 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-11 12:55
Typeset the Manuscript	2022-07-07 09:40

ISSN	2220-3206 (online)
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