Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	75071
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Differences of core genes in liver fibrosis and hepatocellular carcinoma: Evidence from integrated bioinformatics and immunohistochemical analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Li, Shou-Li Yuan, Jing-Ya Yin, Kun Yang, Xin-Gang Zhou, Wen Xie and Qi Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 82170591 National Natural Science Foundation of China (General Program) 81770577
Corresponding Author	Qi Wang, MD, PhD, Reader (Associate Professor), Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 East Jingshun Street, Chaoyang District, Beijing 100015, China. wangqidl04@ccmu.edu.cn
Key Words	Liver cirrhosis; Hepatocellular carcinoma; Bioinformatical analysis; Decorin; Dermatopontin; SRY-box transcription factor 9
Core Tip	GSE14323, GSE36411, and GSE89377 are available from the Gene Expression Omnibus database. Forty-five differentially expressed genes and 10 hub genes were identified between cirrhotic and healthy livers. quantitative polymerase chain reaction, western blot, and immunohistochemistry analyses showed that decorin (DCN), dermatopontin (DPT), and SRY-box transcription factor 9 (SOX9) were highly expressed in the CCl4-induced cirrhotic mouse model. The expression levels of DCN and SOX9 were also significantly increased in HCC patients and were associated with the fibrosis stage. However, overexpression of DPT was only observed in patients with hepatic fibrosis. The Kaplan-Meier curves showed that HCC patients with higher SOX9 expression had significantly lower 5-year survival rates, while patients with over-expression of DCN and DPT had higher 5-year survival rates.
Citation	Li Y, Yuan SL, Yin JY, Yang K, Zhou XG, Xie W, Wang Q. Differences of core genes in liver fibrosis and hepatocellular carcinoma: Evidence from integrated bioinformatics and immunohistochemical analysis. World J Gastrointest Oncol 2022; 14(7): 1265-1280

Received	2022-01-25 02:46
Peer-Review Started	2022-01-25 02:48
To Make the First Decision
Return for Revision	2022-05-10 08:00
Revised	2022-05-18 10:47
Second Decision	2022-06-22 09:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 23:39
Articles in Press	2022-06-26 23:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-06 03:58

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com