Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	75288
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Primary signet-ring cell carcinoma of the extrahepatic bile duct: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chao-Bang Xie, Yang Wu, Feng Li, Kai-Fei Zhao, Rong-Shu Shi, Qiong Huang, Jin Ao and Di Ke
Funding Agency and Grant Number	Funding Agency Grant Number the Zunyi City Science and Technology Department HZ-2021-44
Corresponding Author	Kai-Fei Zhao, Doctor, Associate Professor, Deputy Director, Department of Radiology, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. zhaokaifei8943@sina.com
Key Words	Cholangiocarcinoma; Adenocarcinoma; Signet ring cell carcinoma; Extrahepatic bile duct; Case report
Core Tip	We report a case where an 82-year-old female was admitted with abdominal pain, jaundice, and skin pruritus for 2 mo. The radiological diagnosis was a cholangiocarcinoma. To alleviate jaundice and prolong the overall survival, percutaneous transhepatic cholangiopancreatic drainage (PTCD) was performed. During the operation, in order to determine the nature and origin of the lesion, a biliary biopsy was performed under fluoroscopy. Finally, a diagnosis of primary signet ring cell carcinoma of extrahepatic bile duct with distant lymph node metastasis and multiple liver metastases was made based on the radiographic, PTCD, and pathological characteristics. However, despite active treatment, the disease progressed rapidly, and the patient died after 1 mo due to liver failure.
Citation	Xie CB, Wu Y, Li F, Zhao KF, Shi RS, Huang Q, Ao J, Ke D. Primary signet-ring cell carcinoma of the extrahepatic bile duct: A case report. World J Gastrointest Oncol 2022; 14(7): 1356-1362

Received	2022-01-23 09:42
Peer-Review Started	2022-01-23 09:43
To Make the First Decision
Return for Revision	2022-04-17 18:32
Revised	2022-04-30 11:07
Second Decision	2022-06-20 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 23:40
Articles in Press	2022-06-26 23:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-22 19:07
Typeset the Manuscript	2022-07-02 07:29

ISSN	1948-5204 (online)
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