Publication Name	World Journal of Clinical Oncology
Manuscript ID	75416
Country	Japan

Category	Pharmacology & Pharmacy
Manuscript Type	Retrospective Study
Article Title	Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ako Gannichida, Yusuke Nakazawa, Akira Kageyama, Hirofumi Utsumi, Kazuyoshi Kuwano and Takashi Kawakubo
Funding Agency and Grant Number
Corresponding Author	Yusuke Nakazawa, MDS, Assistant Lecturer, Department of Pharmacy, The Jikei University Hospital, 3-19-18 Nishi Shimbashi, Minato-ku, Tokyo 105-8471, Japan, Tokyo 105-8471, Japan. y_nakazawa@jikei.ac.jp
Key Words	Nivolumab; Hypothyroidism; Immune checkpoint inhibitors; Immune-related adverse event; Neutrophil-to-lymphocyte ratio
Core Tip	This study evaluated whether continuous monitoring of neutrophil-to-lymphocyte ratio (NLR) during nivolumab treatment is useful for predicting the incidence and onset period of hypothyroidism. Patients with hypothyroidism had a significantly lower NLR at treatment initiation, and hypothyroidism incidence was higher among those with NLR < 5. Patients with persistently low NLR (<3.5) developed hypothyroidism earlier than those with an NLR of 3.5 to <5 and ≥5. Low NLR at treatment initiation increases the incidence of treatment-induced hypothyroidism. Furthermore, its persistence may be a risk factor for the early onset of hypothyroidism.
Citation	Gannichida A, Nakazawa Y, Kageyama A, Utsumi H, Kuwano K, Kawakubo T. Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer. World J Clin Oncol 2022; 13(7): 641-651

Received	2022-02-05 09:06
Peer-Review Started	2022-02-05 09:08
To Make the First Decision
Return for Revision	2022-05-12 08:45
Revised	2022-06-01 11:24
Second Decision	2022-06-20 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-27 00:03
Articles in Press	2022-06-27 00:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-01 07:21

ISSN	2218-4333 (online)
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