Publication Name	World Journal of Diabetes
Manuscript ID	75512
Country	Spain

Category	Medicine, General & Internal
Manuscript Type	Review
Article Title	Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease
Manuscript Source	Invited Manuscript
All Author List	María M Adeva-Andany and Natalia Carneiro-Freire
Funding Agency and Grant Number
Corresponding Author	María M Adeva-Andany, MD, PhD, Consultant Physician-Scientist, Nephrology, Hospital Juan Cardona, Pardo Bazán x/n, Ferrol 15406, Spain. madevaa@yahoo.com
Key Words	Diabetes; Kidney disease; Glycosaminoglycans; Factor H; Sialic acid; Laminin; Collagen; Fibronectin-1; Extracellular matrix
Core Tip	Diabetic kidney disease is associated with profound disturbance in glomerular extracellular matrix (ECM). Understanding the mechanisms that regulate glomerular ECM synthesis and repair may contribute to design therapeutic strategies that improve clinical outcomes. The cytoskeleton inside the foot processes of podocytes is connected to the glomerular basement membrane (GBM) via associated proteins. There is a reciprocal interaction between the cellular cytoskeleton and the extracellular tissue that contribute to regulate ECM composition. Loss of anchor points in the GBM may lead to podocyte detachment. Likewise, alterations in the podocyte cytoskeleton may unfasten the cell and impair the filtration barrier.
Citation	Adeva-Andany MM, Carneiro-Freire N. Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease. World J Diabetes 2022; 13(7): 498-520

Received	2022-02-01 15:10
Peer-Review Started	2022-02-01 15:12
To Make the First Decision
Return for Revision	2022-04-18 00:04
Revised	2022-04-19 16:00
Second Decision	2022-06-21 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 23:48
Articles in Press	2022-06-26 23:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-05 14:21

ISSN	1948-9358 (online)
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