Publication Name	World Journal of Meta-Analysis
Manuscript ID	77053
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Difference in incidence of developing hepatocellular carcinoma between hepatitis B virus-and hepatitis C virus-infected patients
Manuscript Source	Unsolicited Manuscript
All Author List	Kazuo Tarao, Akito Nozaki, Hirokazu Komatsu, Naomi Ideno, Tatsuji Komatsu, Takaaki Ikeda, Masataka Taguri and Shin Maeda
Funding Agency and Grant Number
Corresponding Author	Kazuo Tarao, MD, PhD, Director, Deparment of Gastroenterology, Tarao's Gastroenterological Clinic, 3rd Floor, Taiyo-Building, 2-58-6, Futamatagawa, Asahi-ku, , Yokohama city 241-0821, Japan. duoluoweih7@gmail.com
Key Words	Hazard ratio of alanine aminotransferase; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Elevated alanine aminotransferase
Core Tip	It is generally accepted that the incidence of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-associated of patients is higher than that in hepatitis B virus (HBV)-associated patients. We demonstrated that the incidence of HCC in HCV-associated cirrhotic patients was 4.81%/year as compared with 3.23% in HBV-associated patients based on analytic assessment of already published papers. In HBV infection, alanine aminotransferase (ALT) is the second highest risk factor, and in HCV infection, ALT is the highest risk factor, for HCC development. The hazard ratio (HR) for developing HCC in the inflammatory state (serum ALT levels exceeded the normal range) was compared between HBV and HCV patients. In the 14 studies of HBV patients, the average HR was 2.74 as compared with 5.51 in the 8 studies of HCV patients (P = 0.0391). The difference in the incidence of HCC development between HBV and HCV patients may depend on the difference in the hazard risk of ALT for HCC development between HBV and HCV infections.
Citation	Tarao K, Nozaki A, Komatsu H, Ideno N, Komatsu T, Ikeda T, Taguri M, Maeda S. Difference in incidence of developing hepatocellular carcinoma between hepatitis B virus-and hepatitis C virus-infected patients. World J Meta-Anal 2022; 10(3):186-194

Received	2022-04-13 05:07
Peer-Review Started	2022-04-13 05:07
To Make the First Decision
Return for Revision	2022-05-31 07:50
Revised	2022-06-14 05:50
Second Decision	2022-06-27 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-27 19:04
Articles in Press	2022-06-27 19:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-28 07:24

ISSN	2308-3840 (online)
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