Publication Name	World Journal of Gastroenterology
Manuscript ID	79214
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Quantitative parameters in novel spectral computed tomography: Assessment of Ki-67 expression in patients with gastric adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ting Mao, Wei-Cui Chen, Jian-Ye Lu, Han-Liang Zhang, Yong-Song Ye, Yu Zhang, Bo Liu, Wei-Wei Deng and Xian Liu
Funding Agency and Grant Number
Corresponding Author	Xian Liu, PhD, Professor, Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. liuxian74@hotmail.com
Key Words	Spectral computer tomography; Quantitative parameters; Gastric carcinoma; Iodine concentration; Effective atomic number; Ki-67 expression
Core Tip	This is a retrospective study to preoperatively distinguish the expression of Ki-67 index based on the parameters of spectral computer tomography (CT) in patients with gastric adenocarcinoma. The CT attenuation of virtual monoenergetic images in venous phase and effective atomic number were negatively related to the expression of Ki-67, while iodine concentration exhibited positive associations with it. Multi-variable model of spectral parameters exhibited a better diagnostic efficiency than other single-variable model of spectral parameter in discriminating low and high Ki-67 expression of gastric adenocarcinoma.
Citation	Mao LT, Chen WC, Lu JY, Zhang HL, Ye YS, Zhang Y, Liu B, Deng WW, Liu X. Quantitative parameters in novel spectral computed tomography: Assessment of Ki-67 expression in patients with gastric adenocarcinoma. World J Gastroenterol 2023; 29(10): 1602-1613

Received	2022-08-29 10:45
Peer-Review Started	2022-08-29 10:48
To Make the First Decision
Return for Revision	2022-12-12 08:38
Revised	2022-12-23 05:43
Second Decision	2023-01-16 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-16 19:49
Articles in Press	2023-01-16 19:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-02-28 06:01
Typeset the Manuscript	2023-03-06 02:52

ISSN	1007-9327 (print) and 2219-2840 (online)
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