Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	79331
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Xiang Zhang, Sheng-Chuan Bao, Juan Chen, Ting Chen, Hai-Liang Wei, Xiao-Yan Zhou, Jing-Tao Li and Shu-Guang Yan
Funding Agency and Grant Number	Funding Agency Grant Number Shaanxi Science and Technology overall Planning and Innovation Project 2016KTTSSF01-05 Key R & D projects in Shaanxi Province 2022ZDLSF05-10 Shaanxi University of Chinese Medicine Discipline Innovation Team Construction Project 2019-YL-05
Corresponding Author	Shu-Guang Yan, PhD, Professor, College of Basic Medicine, Shaanxi University of Chinese Medicine, Century Avenue, Qindu District, Xianyang 712046, Shaanxi Province, China. ysg2002.student@sina.com
Key Words	Xiaojianzhong decoction; Gastric precancerous lesions; Autophagy; Glycolysis; Gastric mucosal cells; Herb
Core Tip	Xiaojianzhong Decoction is a classic compound for the treatment of digestive system diseases in ancient China, and it also shows good curative effect in the treatment of gastric precancerous lesions (GPL). Many studies have shown that the levels of autophagy and glycolysis influence the progression of GPL. Our study found that Xiaojianzhong Decoction can improve the pathological manifestations of gastric mucosa in GPL rats, and inhibits the expression of autophagy, glycolysis-related proteins and mRNA. Xiaojianzhong decoction (XJZ) prevented the increase of autophagy levels by decreasing gastric mucosal hypoxia, activating the phosphatidylinositol 3-kimase/protein kinase B/mammalian target of rapamycin pathway, inhibiting the p53/AMP-activated protein kinase pathway activation and Unc-51 Like kinase 1 (ULK1) Ser-317 and Ser-555 phosphorylation. In addition, XJZ improved abnormal gastric mucosal glucose metabolism by ameliorating gastric mucosal hypoxia and inhibiting ULK1 expression.
Citation	Zhang JX, Bao SC, Chen J, Chen T, Wei HL, Zhou XY, Li JT, Yan SG. Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells. World J Gastrointest Oncol 2023;15(3): 464-489

Received	2022-08-16 08:36
Peer-Review Started	2022-08-16 08:38
To Make the First Decision
Return for Revision	2022-11-17 08:54
Revised	2022-12-01 03:05
Second Decision	2023-01-16 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-16 19:54
Articles in Press	2023-01-16 19:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-07 03:30
Typeset the Manuscript	2023-02-27 01:12

ISSN	1948-5204 (online)
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