Publication Name	World Journal of Diabetes
Manuscript ID	80299
Country	Mexico

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Insulin: A connection between pancreatic β cells and the hypothalamus
Manuscript Source	Invited Manuscript
All Author List	Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello and Monica Espinoza Rojo
Funding Agency and Grant Number
Corresponding Author	Monica Espinoza Rojo, PhD, Researcher, Molecular and Genomic Biology Laboratory, , Chilpancingo 39070, Guerrero, Mexico., Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Chilpancingo 39090, Guerrero, Mexico. monicaespinoza@uagro.mx
Key Words	Insulin; Pancreas; Hypothalamus; Hyperphagia; Hyperglycemia; Stress
Core Tip	Insulin is the connection between the β cells of the pancreas and the hypothalamus. Insulin reaches the arcuate nucleus of the hypothalamus and represses the expression of orexigenic neuropeptides to suppress appetite. However, its function decreases when there is damage to the β cells of the pancreas. Its anorexigenic effect decreases and thus increases appetite. The excess of nutrients, specifically carbohydrates, aggravates the damage to β cells and induces obesity and/or diabetes and oxidative damage. The use of antioxidants constitutes a therapeutic approach that has been approached experimentally to regulate the negative effects of alterations in insulin secretion and function.
Citation	De la Cruz Concepción B, Flores Cortez YA, Barragán Bonilla MI, Mendoza Bello JM, Espinoza Rojo M. Insulin: A connection between pancreatic β cells and the hypothalamus. World J Diabetes 2023; 14(2): 76-91

Received	2022-10-06 03:21
Peer-Review Started	2022-10-06 03:24
To Make the First Decision
Return for Revision	2022-11-18 07:56
Revised	2022-12-13 21:33
Second Decision	2023-01-16 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-17 06:26
Articles in Press	2023-01-17 06:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-04 00:03
Typeset the Manuscript	2023-02-02 08:27

ISSN	1948-9358 (online)
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