Publication Name	World Journal of Gastroenterology
Manuscript ID	80568
Country	Italy

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Liver involvement in patients with COVID-19 infection: A comprehensive overview of diagnostic imaging features
Manuscript Source	Invited Manuscript
All Author List	Davide Ippolito, Cesare Maino, Federica Vernuccio, Roberto Cannella, Riccardo Inchingolo, Michele Dezio, Riccardo Faletti, Pietro Andrea Bonaffini, Marco Gatti and Sandro Sironi
Funding Agency and Grant Number
Corresponding Author	Davide Ippolito, MD, Associate Professor, Doctor, . davide.atena@tiscali.it
Key Words	Liver; Fatty liver; Hepatomegaly; Hepatic infarction; Liver diseases; Liver failure; Biliary tract diseases; COVID-19; SARS-CoV-2; Infection; X-Ray computed tomography; Magnetic resonance imaging; Ultrasonography; Adults; Pediatrics
Core Tip	Coronavirus disease 2019 (COVID-19) infection has an impact not only on lung involvement but also in other systems, in particular the gastrointestinal one, with a special focus on the liver. Hepatocytes express the receptor of angiotensin-converting enzyme which is the main door of the entrance of severe acute respiratory syndrome coronavirus 2. Consequently, different mechanisms can lead to different hepatic scenarios, such as hepatomegaly, steatosis, steatohepatitis, and drug-induced liver injury. As for lung involvement, the infection can lead to hepatic vascular involvement, especially portal vein thrombosis. Finally, it has been demonstrated a possible biliary involvement in COVID-19 patients.
Citation	Ippolito D, Maino C, Vernuccio F, Cannella R, Inchingolo R, Dezio M, Faletti R, Bonaffini PA, Gatti M, Sironi S. Liver involvement in patients with COVID-19 infection: A comprehensive overview of diagnostic imaging features. World J Gastroenterol 2023; 29(5): 834-850

Received	2022-10-03 20:03
Peer-Review Started	2022-10-03 20:04
To Make the First Decision
Return for Revision	2022-11-26 08:34
Revised	2022-12-06 21:49
Second Decision	2023-01-20 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-20 23:21
Articles in Press	2023-01-20 23:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-14 00:35
Typeset the Manuscript	2023-01-28 03:05

ISSN	1007-9327 (print) and 2219-2840 (online)
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