Publication Name	World Journal of Orthopedics
Manuscript ID	80685
Country	China

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Diagnosis and treatment of chronic osteomyelitis based on nanomaterials
Manuscript Source	Invited Manuscript
All Author List	Ming Zeng, Zheng Xu, Zhen-Qi Song, Jie-Xiao Li, Zhong-Wen Tang, Sheng Xiao and Jie Wen
Funding Agency and Grant Number	Funding Agency Grant Number Science project of Hunan Provincial Health Commission 202204073347
Corresponding Author	Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Key Words	Osteomyelitis; Nanomaterials; Infectious disease; Drug delivery
Core Tip	Chronic osteomyelitis is a painful and serious disease caused by infected surgical prostheses or infected fractures. Traditional treatment includes surgical debridement followed by prolonged systemic antibiotics treatment. But as antibiotics is difficult to penetrate into the internal infection areas of bone, thus limiting the efficacy of systemic antibiotic therapy, new therapeutic approach to treat this disease remains a major challenge for orthopedic surgeons. Substantial progress has been made in constructing antibacterial nanomaterials for treatment of chronic osteomyelitis. We review some current strategies for treatment of chronic osteomyelitis and their underlying mechanisms.
Citation	Zeng M, Xu Z, Song ZQ, Li JX, Tang ZW, Xiao S, Wen J. Diagnosis and treatment of chronic osteomyelitis based on nanomaterials. World J Orthop 2023; 14(2): 42-54

Received	2022-10-09 11:31
Peer-Review Started	2022-10-09 11:33
To Make the First Decision
Return for Revision	2022-11-22 08:59
Revised	2022-12-01 08:22
Second Decision	2023-01-13 03:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-17 18:27
Articles in Press	2023-01-17 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-20 09:39

ISSN	2218-5836 (online)
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