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1/18/2023 11:39:23 PM | Browse: 61 | Download: 106
Publication Name World Journal of Hepatology
Manuscript ID 81760
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List You-Wen Tan, Jia-Min Wang and Xing-Bei Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Social Development Project of Jiangsu Province, China BE2020775
Chinese Federation of Public Health foundation GWLM202002
Corresponding Author You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300, Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu , China. tyw915@sina.com
Key Words Nonalcoholic fatty liver disease; Steatohepatitis; Chronic hepatitis B virus infection; Hepatocellular carcinoma; Cirrhosis
Core Tip A total of 456 patients with chronic hepatitis B virus infection were included in the study, of whom 152 (33.3%) had histologically confirmed nonalcoholic fatty liver disease (NAFLD). The median follow-up time of the entire cohort was 70.5 mo. Kaplan-Meier (K-M) survival analysis showed that NAFLD was not significantly associated with the risk of cirrhosis. Patients with chronic hepatitis B with fibrosis at baseline were more prone to cirrhosis. After PSM, multivariate analysis showed that diabetes mellitus, ballooning deformation, and platelet were independent risk factors for cirrhosis. A total of 10 patients (2.2%) developed hepatocellular carcinoma (HCC). K-M survival analysis showed that the cumulative risk of HCC in the NAFLD group was significantly higher. Cox multivariate analysis revealed that hepatocyte ballooning, liver fibrosis, and diabetes mellitus were independent risk factors for HCC.
Citation Tan YW, Wang JM, Zhou XB. Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease. World J Hepatol 2023; 15(2): 237-254
Received
2022-11-22 22:02
Peer-Review Started
2022-11-22 22:04
To Make the First Decision
Return for Revision
2022-12-10 07:38
Revised
2022-12-14 08:40
Second Decision
2023-01-18 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-01-18 23:39
Articles in Press
2023-01-18 23:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-01-19 09:11
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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