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Publication Name World Journal of Diabetes
Manuscript ID 84398
Country/Territory China
Category Endocrinology & Metabolism
Manuscript Type Observational Study
Article Title Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement
Manuscript Source Unsolicited Manuscript
All Author List Min-Min Han, Jia-Xin Zhang, Zi-Ang Liu, Lin-Xin Xu, Tao Bai, Chen-Yu Xiang, Jin Zhang, Dong-Qing Lv, Yan-Fang Liu, Yan-Hong Wei, Bao-Feng Wu, Yi Zhang and Yun-Feng Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81770776
The Shanxi Provincial Central Leading Local Science and Technology Development Fund Project YDZJSX2022A059
Postgraduate Education Innovation Project of Shanxi Province 2022Y354
National Natural Science Foundation of China 81973378
National Natural Science Foundation of China 82073909
Corresponding Author Yun-Feng Liu, MD, PhD, Chief Physician, Professor, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang Nan Road, Taiyuan 030000, Shanxi Province, China. nectarliu@163.com
Key Words Hypopituitarism; Prednisone; Flash glucose monitoring system; Glucose-target-rate; Glucose variability; Period glucose level
Core Tip Glucocorticoids (GCs) replacement regimens for patients with hypopituitarism are hard to mimic physiological cortisol rhythms and carry risks of over-treatment, which can have adverse effects on glucose metabolism. We assessed the glucose metabolism profile of patients with hypopituitarism receiving prednisone (Pred) replacement, using a flash glucose monitoring system, to clarify impacts of different GCs preparations and prescriptions on glycometabolism, along with the resultant risks of consequent cardiovascular events. The study showed that Pred replacement disturbed glycometabolic homeostasis in patients with hypopituitarism. A dose of > 5 mg/d Pred caused more adverse effects on glycometabolism than ≤ 5 mg/d, contributing to the higher risks of cardiovascular events.
Citation Han MM, Zhang JX, Liu ZA, Xu LX, Bai T, Xiang CY, Zhang J, Lv DQ, Liu YF, Wei YH, Wu BF, Zhang Y, Liu YF. Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement. World J Diabetes 2023; 14(7): 1112-1125
Received
2023-03-13 01:52
Peer-Review Started
2023-03-13 01:52
To Make the First Decision
Return for Revision
2023-05-12 01:36
Revised
2023-05-17 13:03
Second Decision
2023-05-30 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-30 07:13
Articles in Press
2023-05-30 07:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-07-05 09:24
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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