Publication Name	World Journal of Gastroenterology
Manuscript ID	84593
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Stereotactic body radiotherapy combined with sintilimab in patients with recurrent or oligometastatic hepatocellular carcinoma: A phase II clinical trial
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Xing Chen, Ping Yang, Shi-Suo Du, Yuan Zhuang, Cheng Huang, Yong Hu, Wen-Chao Zhu, Yi-Yi Yu, Tian-Shu Liu and Zhao-Chong Zeng
Funding Agency and Grant Number	Funding Agency Grant Number The Ministry of Science and Technology of The People's Republic of China 2022YFC2503700 The Ministry of Science and Technology of The People's Republic of China 2022YFC2503704
Corresponding Author	Zhao-Chong Zeng, PhD, Professor, Department of Radiation Oncology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. zeng.zhaochong@zs-hospital.sh.cn
Key Words	Stereotactic body radiotherapy; Programmed cell death 1; Sintilimab; Hepatocellular carcinoma; Efficacy and safety
Core Tip	In this single-arm phase II trial, stereotactic body radiotherapy (SBRT) plus sintilimab showed outstanding progression-free survival and objective response rate in the treatment of recurrent or oligometastatic hepatocellular carcinoma. Moreover, the combined use of SBRT and sintilimab is safe and tolerable. Patients can recover rapidly from radiotherapy-induced decreases in lymphocyte counts. This result suggests that SBRT combined with sintilimab may be a new treatment option for patients with recurrent or oligometastatic hepatocellular carcinoma.
Citation	Chen YX, Yang P, Du SS, Zhuang Y, Huang C, Hu Y, Zhu WC, Yu YY, Liu TS, Zeng ZC. Stereotactic body radiotherapy combined with sintilimab in patients with recurrent or oligometastatic hepatocellular carcinoma: A phase II clinical trial. World J Gastroenterol 2023; 29(24): 3871-3882

Received	2023-03-26 00:50
Peer-Review Started	2023-03-26 00:52
To Make the First Decision
Return for Revision	2023-04-26 23:35
Revised	2023-05-06 16:02
Second Decision	2023-05-30 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-30 07:11
Articles in Press	2023-05-30 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-14 08:26

ISSN	1007-9327 (print) and 2219-2840 (online)
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