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5/26/2023 12:35:03 AM | Browse: 55 | Download: 0
Publication Name World Journal of Stem Cells
Manuscript ID 84602
Country/Territory China
Category Urology & Nephrology
Manuscript Type Basic Study
Article Title Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis
Manuscript Source Unsolicited Manuscript
All Author List Qiong-Dan Hu, Rui-Zhi Tan, Yuan-Xia Zou, Jian-Chun Li, Jun-Ming Fan, Fahsai Kantawong and Li Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 82205002
Science and Technology Project of Sichuan Province 2022YFS0621, 21ZDYF0348,2022NSFSC1459
the Luzhou-Southwest Medical University Science and Technology Strategic Cooperation Project 2021LZXNYD-P04
the Southwest Medical University of Affiliated Traditional Medicine Hospital Project 2022-CXTD-03
Corresponding Author Li Wang, PhD, Professor, Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou 646000, Sichuan Province, China. wangli120@swmu.edu.cn
Key Words Calycosin; Mesenchymal stem cells; Focal segmental glomerulosclerosis; Apoptosis; Smad3
Core Tip Calycosin (CA)-pretreated mesenchymal stem cells (MSCsCA) enhanced the protective effect of MSCs against adriamycin (ADR)-induced podocyte injury in vitro and in vivo by inhibiting apoptosis, accompanied by more reversal of the upregulated expression of p-Smad3 after ADR induction. Smad3 overexpression eliminated the inhibitory effect of MSCsCA on podocyte apoptosis, suggesting that MSCsCA inhibit podocyte apoptosis by targeting p-Smad3. These results broaden our understanding of the potential of MSCs pretreated with herbal extract and provide new theories for possible therapeutic mechanisms for ADR-induced focal segmental glomerulosclerosis.
Citation Hu QD, Tan RZ, Zou YX, Li JC, Fan JM, Kantawong F, Wang L. Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis. World J Stem Cells 2023; 15(6): 617-631
Received
2023-03-29 03:52
Peer-Review Started
2023-03-29 03:54
To Make the First Decision
Return for Revision
2023-04-25 05:26
Revised
2023-04-28 08:58
Second Decision
2023-05-24 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-05-26 00:35
Articles in Press
2023-05-26 00:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-05-23 01:14
Typeset the Manuscript
2023-06-17 12:28
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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