Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	84710
Country	China

Category	Oncology
Manuscript Type	Case Control Study
Article Title	Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ge-Yu-Jia Zhou, Dong-Yan Zhao, Teng-Fei Yin, Qian-Qian Wang, Yuan-Chen Zhou and Shu-Kun Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Key Development Plan for Precision Medicine Research 2017YFC0910002
Corresponding Author	Shu-Kun Yao, Doctor, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words	Exosomes; Colorectal cancer; Data-independent acquisition; Parallel reaction monitoring; Biomarker
Core Tip	We innovatively combined high-throughput quantitative proteomics analysis with colorectal cancer (CRC) tissue-originated exosomes. The comprehensive proteomic signature of CRC tissue exosomes was described using data-independent acquisition mass spectrometry, which revealed a mass of differentially expressed exosomal proteins. Six promising exosomal proteins, NHP2, OLFM4, TOP1, SAMP, TAGL and TRIM28, were verified by parallel reaction monitoring analysis and receiver operating characteristic curve analysis. The results indicated that these exosomal proteins could become potential diagnostic markers and effective therapeutic targets for CRC.
Citation	Zhou GYJ, Zhao DY, Yin TF, Wang QQ, Zhou YC, Yao SK. Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer. World J Gastrointest Oncol 2023; 15(7): 1227-1240

Received	2023-03-26 02:23
Peer-Review Started	2023-03-26 02:26
To Make the First Decision
Return for Revision	2023-04-18 02:57
Revised	2023-04-28 23:05
Second Decision	2023-05-25 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-25 09:19
Articles in Press	2023-05-25 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-07-04 06:57

ISSN	1948-5204 (online)
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