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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 85373
Country Greece
Category Surgery
Manuscript Type Systematic Reviews
Article Title Comparison between upfront surgery and neoadjuvant chemotherapy in patients with locally advanced gastric cancer: A systematic review
Manuscript Source Invited Manuscript
All Author List Stylianos Fiflis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Gregory Christodoulidis, Eleni Louri, Vasileios N Papadopoulos and Dimitrios Giakoustidis
Funding Agency and Grant Number
Corresponding Author Gregory Christodoulidis, PhD, Surgeon, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Key Words Gastric cancer; Locally advanced gastric cancer; Neoadjuvant chemotherapy; Surgery; Survival
Core Tip Gastric cancer (GC) is a major concern worldwide. According to Globocan there were 1089000 new cases of GC and 768000 GC related deaths worldwide in 2020 with almost twice the prevalence and mortality in males than in females. The highest prevalence is observed in Eastern Asia whereas the lowest in Africa. Gastrectomy is the mainstay approach in patients that can undergo surgery and in recent years with the advances in chemotherapy, neoadjuvant chemotherapy (NAT) has shown potential for better survival chances. That is particularly relevant in patients with locally advanced GC as NAT could potentially lead to tumor downsizing thus allowing for higher complete resection rate. In our review we compare patients receiving NAT and then undergoing D2 gastrectomy to those undergoing upfront surgery.
Citation Fiflis S, Papakonstantinou M, Giakoustidis A, Christodoulidis G, Louri E, Papadopoulos VN, Giakoustidis D. Comparison between upfront surgery and neoadjuvant chemotherapy in patients with locally advanced gastric cancer: A systematic review. World J Gastrointest Surg 2023; 15(8): 1808-1818
Received
2023-04-24 17:15
Peer-Review Started
2023-04-24 17:18
To Make the First Decision
Return for Revision
2023-06-01 10:21
Revised
2023-06-07 17:55
Second Decision
2023-06-27 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2023-06-27 09:21
Articles in Press
2023-06-27 09:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-07-21 02:27
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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