Publication Name	World Journal of Gastroenterology
Manuscript ID	88022
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Lei Zhao, Yue Qi, Yi-Fan Wang, Yi Wang, Hui Liang and Ya-Bin Pu
Funding Agency and Grant Number
Corresponding Author	Ya-Bin Pu, MMed, Associate Chief Physician, Department of General Surgery, Naval Medical Center of PLA, No. 338 Huaihai Road, Changning District, Shanghai 200052, China. yabinpu26@163.com
Key Words	Colorectal cancer; 5-methoxytryptophan; Apoptosis; Cell cycle arrest; PI3K/Akt signaling pathway
Core Tip	Colorectal cancer (CRC) is insensitive to radiotherapy and has poor therapeutic efficacy, and there is an urgent need to find new therapeutic targets to prolong patient survival. 5-methoxytryptophan (5-MTP) is a tryptophan metabolite present in both animals and humans. 5-MTP has a wide range of physiological functions such as stabilizing endothelial function, anti-inflammation, and antioxidant to prevent cellular damage. Our study found that 5-MTP combined with an inhibitor of the PI3K/Akt/FoxO3a signaling pathway significantly promoted apoptosis and cell cycle arrest and inhibited cell proliferation in CRC cells compared with 5-MTP alone.
Citation	Zhao TL, Qi Y, Wang YF, Wang Y, Liang H, Pu YB. 5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer. World J Gastroenterol 2023; 29(47): 6148-6160

Received	2023-09-06 08:04
Peer-Review Started	2023-09-06 08:07
To Make the First Decision
Return for Revision	2023-11-01 04:31
Revised	2023-11-04 10:09
Second Decision	2023-11-23 03:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-04 06:07
Articles in Press	2023-12-04 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-15 02:13

ISSN	1007-9327 (print) and 2219-2840 (online)
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