Publication Name	World Journal of Diabetes
Manuscript ID	90221
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance
Manuscript Source	Unsolicited Manuscript
All Author List	xiao ming Liu, Zheng Xiu-li, Ying Ning, Shijia Nie, Xuqiong Wang, Hongyi Jia and Shiqing Yuan
Funding Agency and Grant Number	Funding Agency Grant Number the Preresearch Project of the National Natural Science Foundation of China ZRYY1906 the Applied Basic Research Project of the Science and Technology Department of Sichuan Province 2021YJ0154 the Talent Research Promotion Plan of Xinglin Scholars of Chengdu University of Traditional Chinese Medicine QNXZ2019035 the Chengdu University of Traditional Chinese Medicine ‘Xinglin Scholars' subject talent research promotion Program (young scholars) QNXZ2019037
Corresponding Author	Zheng Xiu-li, PhD, Lecturer, Professor, School of Basic Medicine , Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue,Wenjiang District,Chengdu, Sichuan, China 611137, Chengdu 611137, Sichuan Province, China. zhengxl023@163.com
Key Words	Lingguizhugan decoction; High-fat diet-induced insulin resistance; Amino acid metabolism; S6K1
Core Tip	This research examines the therapeutic properties of Lingguizhugan (LGZG) decoction, specifically focusing on its potential impact on insulin resistance (IR) and its associated mechanisms. The findings indicate that the LGZG decoction effectively controls the S6 kinase beta 1 metabolic pathway, enhancing IR, weight management, glucose tolerance, and liver steatosis. The findings of this study indicate that LGZG decoction can be used as a medical treatment for the control of IR. These results offer valuable clinical insights and propose avenues for future pharmacological investigations.
Citation	Liu XM, Yuan SQ, Ning Y, Nie SJ, Wang XQ, Jia HY, Zheng XL. Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance. World J Diabetes 2024; In press

Received	2023-11-28 13:44
Peer-Review Started	2023-11-27 13:15
To Make the First Decision
Return for Revision	2024-01-17 02:58
Revised	2024-02-06 13:06
Second Decision	2024-03-22 00:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-29 04:19
Articles in Press	2024-03-29 04:19
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Typeset the Manuscript

ISSN	1948-9358 (online)
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