Publication Name	World Journal of Hepatology
Manuscript ID	91431
Country	Nepal

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Subclinical hepatitis E virus genotype 1 infection: The concept of “dynamic human reservoir”
Manuscript Source	Invited Manuscript
All Author List	Ananta Shrestha, Suresh Basnet and Sudhamshu KC
Funding Agency and Grant Number
Corresponding Author	Sudhamshu KC, PhD, Professor, Department of Hepatology, National Academy of Medical Sciences, Mahabouddha, Kathmandu 44600, Nepal. sudhamshu.liver@gmail.com
Key Words	Hepatitis E; Viral hepatitis; Genotype 1; Dynamic human reservoir; Subclinical infection
Core Tip	Epidemiology of hepatitis E virus (HEV) is yet to be known and unraveled. HEV genotype 1 outbreaks tend to reoccur in periodic fashion in certain endemic areas. The virus often disappears even during conducible seasons and living conditions in between these outbreaks. There are no known animal reservoirs for human HEV genotype 1. Occurrence of asymptomatic viremia and transmission during epidemic quiescence in endemic areas may show humans acting as transient reservoir keeping the virus viable in the community. We propose this phenomenon as “Dynamic Human Reservoir” and emphasize the need for further research and data on this area for better understanding of HEV epidemiology.
Citation	Shrestha A, Basnet S, KC S. Subclinical hepatitis E virus genotype 1 infection: The concept of “dynamic human reservoir”. World J Hepatol 2024; 16(4): 506-510

Received	2023-12-28 08:51
Peer-Review Started	2023-12-28 08:54
To Make the First Decision
Return for Revision	2024-02-06 21:58
Revised	2024-02-22 04:48
Second Decision	2024-03-28 01:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 05:48
Articles in Press	2024-03-28 05:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-16 01:22

ISSN	1948-5182 (online)
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