Publication Name	World Journal of Stem Cells
Manuscript ID	91531
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Interplay between mesenchymal stem cells and macrophages: Promoting bone tissue repair
Manuscript Source	Invited Manuscript
All Author List	Fei-Fan Zhang, Yang Hao, Kuai-Xiang Zhang, Jiang-Jia Yang, Zhi-Qiang Zhao, Hong-Jian Liu and Ji-Tian Li
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2023YFC2508806 Key Research and Development Project in Henan Province 231111310500 Young Elite Scientists Sponsorship Program by CAST 2021-QNRC2-A06 Scientific Research Project of Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation ZYYC2023ZD Youth Science Award Project of the Provincial-Level Joint Fund for Science and Technology Research and Development Project in Henan Province 225200810084 Special Project on Training Top Talents in Traditional Chinese Medicine in Henan Province 2022ZYBJ24 2023 Hunan University of Chinese Medicine Postgraduate Innovation Project 2023CX64
Corresponding Author	Ji-Tian Li, MD, PhD, Doctor, Doctor, Professor, Molecular Biology Lab, Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), No. 100 Yongping Road, Zhengzhou 450000, Henan Province, China. jitianlee@hotmail.com
Key Words	Bone tissue damage; Inflammation; Macrophages; Mesenchymal stem cells; Tissue regeneration
Core Tip	Bone regeneration has always been a challenge and priority in the treatment of orthopedic diseases. The interaction between mesenchymal stem cells (MSCs) and macrophages mediating the multilineage differentiation potential and immunomodulatory capabilities plays a crucial role in bone tissue repair and remodeling. Therefore, we reviewed the interactions between MSCs and macrophages, summarized the roles and potential of MSCs and macrophages in bone tissue regeneration, and looked forward to how to better utilize their relationship to enhance the efficacy of MSCs therapy in orthopedic diseases such as bone defects and osteoarthritis.
Citation	Zhang FF, Hao Y, Zhang KX, Yang JJ, Zhao ZQ, Liu HJ, Li JT. Interplay between mesenchymal stem cells and macrophages: Promoting bone tissue repair. World J Stem Cells 2024; 16(4): 375-388

Received	2023-12-30 07:46
Peer-Review Started	2023-12-30 07:46
To Make the First Decision
Return for Revision	2024-01-17 09:22
Revised	2024-02-14 01:43
Second Decision	2024-03-19 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-19 08:30
Articles in Press	2024-03-19 08:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-18 09:26

ISSN	1948-0210 (online)
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