Publication Name	World Journal of Diabetes
Manuscript ID	93907
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study
Manuscript Source	Unsolicited Manuscript
All Author List	Lan-Gen Zhuang, Rong Zhang, Guo-Xi Jin, Xiao-Yan Pei, Qiong Wang and Xiao-Xu Ge
Funding Agency and Grant Number	Funding Agency Grant Number General project of Anhui Provincial Health and Construction Commission No. AHWJ2022b056
Corresponding Author	Xiao-Xu Ge, MD, Doctor, Doctor, Department of Endocrinology, Tongren Hospital Affiliated to Shanghai Jiao Tong University, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. uyhyt41964@163.com
Key Words	Asiaticoside; Diabetic nephropathy; Inflammation; Renal fibrosis; Reactive oxygen species
Core Tip	This study investigates the protective effects of asiaticoside (AC) in diabetic nephropathy (DN) using in vitro and in vivo models. AC attenuated high glucose-induced proliferation, inflammation, oxidative stress, and fibrosis in rat glomerular mesangial cells. In a streptozotocin-induced DN rat model, AC ameliorated renal injury, reduced inflammatory cytokines, oxidative stress markers, and fibrogenic markers. Notably, the renoprotective effects of AC were associated with the activation of the nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 antioxidant signaling pathway, suggesting AC’s therapeutic potential for DN by targeting inflammation, oxidative stress, and fibrosis through the NRF2 mechanism.
Citation	<p>Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX. Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study. <i>World J Diabetes</i> 2024; 15(10): 2111-2122</p>

Received	2024-03-07 13:10
Peer-Review Started	2024-03-07 13:10
To Make the First Decision
Return for Revision	2024-04-17 07:49
Revised	2024-05-30 10:05
Second Decision	2024-07-08 08:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-22 08:36
Articles in Press	2024-07-22 08:36
Publication Fee Transferred	2024-07-29 04:15
Edit the Manuscript by Language Editor	2024-09-01 09:23
Typeset the Manuscript	2024-09-18 04:56

ISSN	1948-9358 (online)
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