Publication Name	World Journal of Diabetes
Manuscript ID	95431
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Kun Wang, Chu-Chu Kong, Ting-Yan Yu, Hui-Song Sun, Lu Yang, Ying Sun, Ming-Yu Li and Wei Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China No. 81471081 Natural Science Foundation of Fujian Province No. 2023D009 Natural Science Foundation of Xiamen City No. 3502Z202373104 Natural Science Foundation of Xiamen City No. 3502Z20227162 Scientific Research Foundation for Advanced Talents, Xiang’an Hospital of Xiamen University No. PM201809170005
Corresponding Author	Wei Wang, Chief Physician, MD, Professor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang’an East Road, Xiang’an District, Xiamen 361102, Fujian Province, China. wwei19742007@hotmail.com
Key Words	β-cell dedifferentiation; High glucose and palmitic acid; Forkhead box O1; RNA-sequencing; Endoplasmic reticulum stress
Core Tip	β-cell dedifferentiation is one of the mechanisms of β cell dysfunction, but the underlying mechanisms remain unclear. In this study, we established an in vitro model of β-cell dedifferentiation induced by high-glucose and palmitic acid, and showed that the inhibition of forkhead box O1 can further enhance these phenomena. We found that high glucose and palmitic acid treatments significantly downregulated the expression of β-cell-specific markers and upregulated the expression of β-cell-disabling genes and endocrine precursor cell marker genes by RNA-sequencing, and that endoplasmic reticulum stress is the key to β-cell dedifferentiation. This study will be beneficial for investigating the mechanism of β-cell dysfunction caused by dedifferentiation.
Citation	<p>Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY, Wang W. Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation. <i>World J Diabetes</i> 2025; 16(5): 95431</p>

Received	2024-07-31 01:47
Peer-Review Started	2024-04-10 07:35
To Make the First Decision
Return for Revision	2024-12-11 08:58
Revised	2025-01-13 07:58
Second Decision	2025-03-24 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-24 05:59
Articles in Press	2025-03-24 05:59
Publication Fee Transferred	2025-01-16 14:03
Edit the Manuscript by Language Editor	2025-03-29 00:39
Typeset the Manuscript	2025-04-11 05:43

ISSN	1948-9358 (online)
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