Publication Name	World Journal of Diabetes
Manuscript ID	96060
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Systematic Reviews
Article Title	Safety of teplizumab in patients with high-risk for diabetes mellitus type 1: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Venkata Buddhavarapu, Gagandeep Dhillon, Harpreet Grewal, Pranjal Sharma, Rahul Kashyap and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, FACP, FCCP, MD, MHSc, Adjunct Professor, Department of Medicine & Pharmacology, Texas A&M University, 40 Bizzell Street, College Station, TX 77843, United States. srsurani@hotmail.com
Key Words	Teplizumab; Diabetes mellitus type 1; Adverse effects; Monoclonal antibody; Systematic review
Core Tip	Teplizumab is an anti-CD4 antibody that has been shown to delay the clinical onset of diabetes mellitus type 1. Our systematic review evaluates the incidence of total adverse effects and a systems-based risk reported in various clinical trials. Our review shows an increased incidence of adverse effects in patients receiving Teplizumab compared to placebo, but this risk is not statistically significant. There is also a statistically significant increased risk of gastrointestinal, dermatological, and hematological adverse effects in the Teplizumab group compared to placebo. More trials need to be conducted to understand better the risk of side effects related to Teplizumab.
Citation	<p>Buddhavarapu V, Dhillon G, Grewal H, Sharma P, Kashyap R, Surani S. Safety of teplizumab in patients with high-risk for diabetes mellitus type 1: A systematic review. <i>World J Diabetes</i> 2024; 15(8): 1793-1801</p>

Received	2024-04-25 14:19
Peer-Review Started	2024-04-25 14:19
To Make the First Decision
Return for Revision	2024-06-15 04:10
Revised	2024-06-24 16:57
Second Decision	2024-07-08 08:58
Accepted by Journal Editor-in-Chief	2024-07-14 14:02
Accepted by Executive Editor-in-Chief	2024-07-17 07:05
Articles in Press	2024-07-17 07:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-19 03:57

ISSN	1948-9358 (online)
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