Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98243
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Li Wang, Zhe Zhang and Hai-Zhang Ma
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Development Plan Project of Hangzhou No. 20201203B56
Corresponding Author	Zhe Zhang, Doctor, Doctor, Doctor, Department of Emergency Medicine, The First People’s Hospital of Linping District Hangzhou, No. 369 Yingbin Road, Nanyuan Street, Linping District, Hangzhou 311100, Zhejiang Province, China. zz2516116@163.com
Key Words	PEA3 subfamily; Cholangiocarcinoma; The cancer genome atlas; ETV4; The prognosis; Prognostic biomarker
Core Tip	This study investigates the expression of the PEA3 subfamily genes (ETV1, ETV4, ETV5) in cholangiocarcinoma (CCA) and their clinical relevance. Using data from cancer genome atlas and genotype-tissue expression project databases, we identified significantly elevated levels of ETV1, ETV4 and ETV5 in CCA. High expression of ETV1 and ETV4 was explicitly correlated with shorter overall survival in CCA patients. Functional assays demonstrated that silencing PEA3 genes reduces invasion and metastasis in CCA cells in vitro and in vivo. These findings suggest that ETV4 may be a valuable prognostic biomarker for survival of CCA patients.
Citation	<p>Wang L, Zhang Z, Ma HZ. Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(9): 4014-4027</p>

Received	2024-06-21 06:22
Peer-Review Started	2024-06-21 06:22
To Make the First Decision
Return for Revision	2024-07-13 05:46
Revised	2024-07-19 01:43
Second Decision	2024-07-30 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-30 06:26
Articles in Press	2024-07-30 06:26
Publication Fee Transferred	2024-07-31 00:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-19 06:05

ISSN	1948-5204 (online)
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