Publication Name	World Journal of Gastroenterology
Manuscript ID	98806
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Tong Qiu, Xin-Yi Luo, Ya-Feng Deng, Xue Zheng, Jian-Guo Qiu, Lin-Sheng Zhang, Xiao-Qi Huang, Xue-Bao Zheng and Hai-Yang Huang
Funding Agency and Grant Number	Funding Agency Grant Number Basic and Applied Basic Research Foundation of Guangdong Province 2021B1515140043 Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515140124 Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515140115
Corresponding Author	Xue-Bao Zheng, PhD, Professor, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232 East Ring Road, University City, Panyu District, Guangzhou 525000, Guangdong Province, China. xuebaozheng@gzucm.edu.cn
Key Words	Modified Pulsatilla decoction; Intestinal mucositis; Oxidative stress; Gut microbiota, TLR4/MyD88/NF-κB pathway; Inflammatory response
Core Tip	Developing safe and effective drugs for the treatment of intestinal mucositis (IM) is of great significance because IM is a common and severe complication of chemotherapy that can lead to a spectrum of gastrointestinal toxicities and even death. In this study, modified Pulsatilla decoction (PD) demonstrated significant efficacy in alleviating 5-fluorouracil-induced IM in mice. The treatment significantly improved key clinical symptoms, including weight loss, diarrhea, and intestinal damage, through modulation of the TLR4/MyD88/NF-κB pathway and restoration of intestinal microbiota balance. These findings provide a novel scientific foundation for the potential clinical application of modified PD in IM management.
Citation	<p>Qiu YT, Luo XY, Deng YF, Zheng X, Qiu JG, Zhang LS, Huang XQ, Zheng XB, Huang HY. Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota. <i>World J Gastroenterol</i> 2025; 31(7): 98806</p>

Received	2024-08-19 07:39
Peer-Review Started	2024-07-06 05:20
To Make the First Decision
Return for Revision	2024-11-10 04:35
Revised	2024-11-19 13:15
Second Decision	2024-12-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-25 07:02
Articles in Press	2024-12-25 07:02
Publication Fee Transferred	2024-11-25 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-10 02:59

ISSN	1007-9327 (print) and 2219-2840 (online)
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