Publication Name	World Journal of Hepatology
Manuscript ID	98971
Country	Malaysia

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective
Manuscript Source	Invited Manuscript
All Author List	Nabil Eid, Payal Bhatnagar, Li-Li Chan and Marina Garcia-Macia
Funding Agency and Grant Number
Corresponding Author	Nabil Eid, MD, PhD, Assistant Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words	Steatosis; Liver; Xiaoyao San; Inflammation; Androgen; Adenosine 5’-monophosphate-activated protein kinase; Phosphatase and tensin homolog; Autophagy; Lipophagy; Alpha smooth muscle actin
Core Tip	Modified Xiaoyao San (MXS) formula has hepato-protective effects in a male rat model of non-alcoholic steatohepatitis (NASH) via suppression of steatosis and inflammation. These protective effects are related to several mechanisms, including the regulation of sex hormone metabolism, androgen upregulation, adenosine 5’-monophosphate-activated protein kinase activation, and enhanced phosphatase and tensin homolog expression. A deeper understanding of the mechanisms behind MXS-induced reduction of hepatic steatosis could assist in the treatment of NASH and related diseases.
Citation	<p>Eid N, Bhatnagar P, Chan LL, Garcia-Macia M. Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective. <i>World J Hepatol</i> 2024; 16(10): 1208-1212</p>

Received	2024-07-10 09:45
Peer-Review Started	2024-07-10 09:45
To Make the First Decision
Return for Revision	2024-09-18 04:03
Revised	2024-09-24 11:26
Second Decision	2024-10-11 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-11 08:48
Articles in Press	2024-10-11 08:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-14 03:10

ISSN	1948-5182 (online)
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