Publication Name	World Journal of Clinical Cases
Manuscript ID	99043
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Atezolizumab and bevacizumab combination in advanced hepatocellular carcinoma patients: The imperative for safety assessment studies
Manuscript Source	Invited Manuscript
All Author List	Mina Tharwat, Ahmed Tawheed and Mohamed El-Kassas
Funding Agency and Grant Number
Corresponding Author	Mohamed El-Kassas, MD, Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Ain Helwan, Cairo 11795, Egypt. m_elkassas@hq.helwan.edu.eg
Key Words	Hepatocellular carcinoma; Atezolizumab; Bevacizumab; Hemorrhage; Side effects
Core Tip	In this article, we comment on the case report by Park et al, published in the recently reporting a fatal intra-tumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab. Multiple predictive factors have been reported to be associated with such condition. They can be categorized as either patient-related (age, systemic hypertension, and use of anticoagulants), liver disease-related (degree of liver decompensation and thrombocytopenia), or tumor-related (portal vein thrombosis). However, future studies are required to assess the long-term safety of this combination in patients with hepatocellular carcinoma.
Citation	<p>Tharwat M, Tawheed A, El-Kassas M. Atezolizumab and bevacizumab combination in advanced hepatocellular carcinoma patients: The imperative for safety assessment studies. <i>World J Clin Cases</i> 2025; 13(9): 99043</p>

Received	2024-07-11 21:32
Peer-Review Started	2024-07-11 21:32
To Make the First Decision
Return for Revision	2024-11-15 07:15
Revised	2024-11-18 07:51
Second Decision	2024-12-02 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-02 07:26
Articles in Press	2024-12-02 07:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-09 00:24

ISSN	2307-8960 (online)
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