Publication Name	World Journal of Gastroenterology
Manuscript ID	99629
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Yen-Yang Chen, Chen-Chi Wang, Chun-Yi Chuang, Yung-An Tsou, Yen-Chun Peng, Chi-Sen Chang and Han-Chung Lien
Funding Agency and Grant Number
Corresponding Author	Han-Chung Lien, MD, PhD, Associate Professor, Division of Gastroenterology, Center for Functional Esophageal Disorders, Taichung Veterans General Hospital, No. 1650 Taiwan Boulevard, Section 4, Taichung 435, Taiwan. lhc@vghtc.gov.tw
Key Words	Pharyngeal acid reflux episodes; Laryngopharyngeal reflux; Hypopharyngeal multichannel intraluminal impedance-potential of hydrogen; 3- potential of hydrogen-sensor; Proton pump inhibitors
Core Tip	This study examines the link between pharyngeal acid reflux (PAR) episodes and the effectiveness of proton pump inhibitor (PPI) therapy in laryngopharyngeal reflux (LPR) patients. Using specific potential of hydrogen criteria for PAR episodes detected by hypopharyngeal multichannel intraluminal impedance-potential of hydrogen, researchers found that patients with ≥ 2 baseline PAR episodes had a significantly higher response rate (73%) to PPI therapy compared to those without acidic reflux (33%). These findings underscore the importance of hypopharyngeal reflux monitoring, as PAR episodes appear to be crucial in predicting PPI efficacy. Hence, the authors recommend a personalized approach to LPR diagnosis and treatment in order to enhance patient outcomes.
Citation	<p>Chen YY, Wang CC, Chuang CY, Tsou YA, Peng YC, Chang CS, Lien HC. Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy. <i>World J Gastroenterol</i> 2024; 30(48): 5162-5173</p>

Received	2024-07-27 02:37
Peer-Review Started	2024-07-27 02:37
To Make the First Decision
Return for Revision	2024-09-04 02:16
Revised	2024-09-17 16:58
Second Decision	2024-10-22 03:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-22 05:38
Articles in Press	2024-10-22 05:38
Publication Fee Transferred	2024-10-24 03:20
Edit the Manuscript by Language Editor	2024-11-13 03:29
Typeset the Manuscript	2024-11-19 07:44

ISSN	1007-9327 (print) and 2219-2840 (online)
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