Publication Name	World Journal of Virology
Manuscript ID	62506
Country	Greece

Category	Endocrinology & Metabolism
Manuscript Type	Evidence-Based Medicine
Article Title	Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach
Manuscript Source	Unsolicited Manuscript
All Author List	Dimitrios T Papadimitriou, Alexandros K Vassaras and Michael F Holick
Funding Agency and Grant Number
Corresponding Author	Dimitrios T Papadimitriou, MD, MSc, PhD, Director, Director, Pediatric - Adolescent Endocrinology & Diabetes, Athens Medical Center, 58, Kifisias av., Marousi 15125, Greece. info@pedoendo.net
Key Words	COVID-19; SARS-CoV-2; Vitamin D status; Vitamin D concentrations; 25-hydroxyvitamin-D; Immunity
Core Tip	To elucidate the role of vitamin D in the coronavirus disease 2019 (COVID-19) pandemic, we examined associations between published representative and standardized European population vitamin D data and the Worldometer COVID-19 data. Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/million (M), but negative correlations predicting a reduction of 47%-64%-80% in serious-critical illnesses/M and of 61%-82%-102.4% in deaths/M, further enhanced when adapting for life expectancy by 133-177-221% if 25-hydroxyvitamin-D concentrations reach 100-125-150 nmol/L. Weighted ANOVA/ANCOVA showed a decreasing trend (P < 0.001) evaluating serious-critical/M (r2 = 0.22), and the deaths/M (r2 = 0.629) after controlling for life expectancy (r2 = 0.47), by vitamin D population status, respectively.
Citation	Papadimitriou DT, Vassaras AK, Holick MF. Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach. World J Virol 2021; 10(3): 111-129

Received	2021-01-10 22:12
Peer-Review Started	2021-01-10 22:13
To Make the First Decision
Return for Revision	2021-02-15 03:37
Revised	2021-02-21 01:35
Second Decision	2021-04-07 12:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-04-07 17:21
Articles in Press	2021-04-07 17:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-15 18:54
Typeset the Manuscript	2021-04-29 07:21

ISSN	2220-3249 (online)
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