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Articles in Press
8/1/2025 1:20:58 PM | Browse: 117 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Inflammation and detection: Rethinking the biomarker landscape in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keykavous Parang and Koosha Paydary |
| Funding Agency and Grant Number |
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| Corresponding Author |
Keykavous Parang, Full Professor, PharmD, PhD, Professor, Tenured Professor, Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, 9401 Jeronimo Road, Irvine, CA 92618, United States. parang@chapman.edu |
| Key Words |
Biomarker; Cytokine; Diagnosis; Gastric carcinoma; Inflammation; Pro-inflammatory |
| Core Tip |
This letter evaluates the diagnostic and therapeutic utility of key inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, and interferon-gamma, in gastric carcinoma (GC). These molecules are discussed as both biomarkers and drivers of tumor progression and chemoresistance. The discussion situates these markers within a broader inflammatory biomarker landscape that includes IL-10, IL-11, IL-18, C-X-C motif ligand 9, and host genetic factors. The analysis supports the use of multiplex cytokine panels over single markers for GC detection and treatment stratification, and outlines future directions for clinical integration and biomarker-guided therapy. |
| Citation |
Parang K, Paydary K. Inflammation and detection: Rethinking the biomarker landscape in gastric cancer. World J Clin Oncol 2025; 16(9): 109717 |
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Received |
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2025-05-20 07:01 |
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Peer-Review Started |
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2025-05-20 07:01 |
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First Decision by Editorial Office Director |
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2025-06-23 01:42 |
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Return for Revision |
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2025-06-23 01:42 |
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Revised |
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2025-07-05 17:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-08-01 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-01 13:20 |
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Articles in Press |
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2025-08-01 13:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-01 06:00 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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