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8/16/2017 5:51:11 PM | Browse: 356 | Download: 134
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 32829
Country/Territory Germany
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Paneth cells in intestinal physiology and pathophysiology
Manuscript Source Invited Manuscript
All Author List Nikolaus Gassler
Funding Agency and Grant Number
Corresponding Author Nikolaus Gassler, MA, Professor, Institute of Pathology, RWTH Aachen University, Celler Strasse 38, Braunschweig 38114, Germany. ngassler@ukaachen.de
Key Words Antimicrobial peptide; Paneth cell; Crohn’s disease; Microbiome; Small intestine
Core Tip Paneth cells physiologically locate in small intestinal crypts. Wnt signalling promotes their differentiation and movement into crypts, whereas Notch activities antagonise Paneth cell maturation. The cells essentially contribute to crypt morphogenesis and intestinal homeostasis, sharpening the microbiome by secreting antimicrobial peptides, like defensins, and crypt fission. There is increasing molecular evidence that Paneth cells disorders are strongly involved in the pathophysiology of several intestinal diseases including ileal Crohn’s disease and necrotising enterocolitis.
Citation Gassler N. Paneth cells in intestinal physiology and patho¬physiology. World J Gastrointest Pathophysiol 2017; 8(4): 150-160
Received
2017-01-26 21:32
Peer-Review Started
2017-01-26 22:18
To Make the First Decision
2017-04-17 09:27
Return for Revision
2017-05-02 21:05
Revised
2017-07-28 17:07
Second Decision
2017-08-11 07:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-16 17:51
Articles in Press
2017-08-16 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-11-02 07:47
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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