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5/31/2017 2:46:12 AM | Browse: 91 | Download: 47
Publication Name World Journal of Clinical Oncology
Manuscript ID 33274
Country of Manuscript Source Canada
Specialty Oncology
Manuscript Type Case Report
Article Title Long-term stabilization of metastatic melanoma using sodium dichloroacetate therapy
Manuscript Source Invited Manuscript
All Author List Akbar Khan, Doug Andrews, Jill Shainhouse, and Anneke C Blackburn
Funding Agency and Grant Number
Correspondence To Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc, 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan@medicorcancer.com
Keywords Dichloroacetate; Cancer; Melanoma; Cytostatic; BRAF
Core Tip Sodium dichloroacetate (DCA) has been under investigation as a metabolic therapy for various types of cancer since 2007. It has been shown that DCA therapy can result in a classic response which is measured by tumour reduction or disappearance on imaging. However, DCA can also act as a cytostatic agent, without causing apoptosis (programmed cell death). This can result in long-term stabilization of metastatic cancer. A case is presented in which oral DCA therapy resulted in reduction and stabilization of metastatic melanoma in a 32 years old male for over 4 years, with only minor side effects.
Citation Khan A, Andrews D, Shainhouse J, Blackburn AC. Long-term stabilization of metastatic melanoma using sodium dichloroacetate therapy. World J Clin Oncol 2017; In press
Received
2017-02-08 11:09
Peer-Review Started
2017-02-12 21:53
To Make the First Decision
2017-03-27 11:21
Return for Revision
2017-03-28 15:30
Revised
2017-04-12 11:39
Second Decision
2017-05-11 13:48
Accepted by Journal Editor-in-Chief
2017-05-11 23:16
Accepted by Company Editor-in-Chief
2017-05-31 02:46
Articles In Press
2017-05-31 02:46
Publication Fee Transferred
Edit the Manuscript by Languag Editor
Typeset the Manuscript
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 03086186
Editorial Director Xiu-Xia Song
Journal Chief Editor Godefridus J Peters
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 33274-Review.docx
Peer-review Report 33274-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33274-Journal editor-in-chief review report.pdf
Answering Reviewers 33274-Answering reviewers.pdf
Scientific Misconduct Check 33274-Scientific misconduct check.pdf
Scientific Editor Work List 33274-Scientific editor work list.pdf
Audio 33274-Audio core tip.mp3
Conflict-of-Interest Statement 33274-Conflict-of-interest statement.pdf
Copyright Assignment 33274-Copyright assignment.pdf
Informed Consent Statement 33274-Informed consent statement.pdf
Institutional Review Board Statement 33274-Institutional review board statement.pdf