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5/31/2017 2:46:12 AM | Browse: 545 | Download: 522
Publication Name World Journal of Clinical Oncology
Manuscript ID 33274
Country/Territory Canada
Category Oncology
Manuscript Type Case Report
Article Title Long-term stabilization of metastatic melanoma with sodium dichloroacetate
Manuscript Source Invited Manuscript
All Author List Akbar Khan, Doug Andrews, Jill Shainhouse and Anneke C Blackburn
Funding Agency and Grant Number
Corresponding Author Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc, 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan@medicorcancer.com
Key Words Dichloroacetate; Cancer; BRAF; Melanoma; Cytostatic
Core Tip Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007. It has been shown that DCA therapy can result in a classic response which is measured by reduction or disappearance of tumours on imaging. However, DCA can also halt cancer cell growth without causing apoptosis (cytostatic effect). This can result in long-term stabilization of metastatic cancer. We present a case of oral DCA therapy resulting in reduction and stabilization of metastatic melanoma in a 32-year-old male for over 4 years, with only minor side effects.
Citation Khan A, Andrews D, Shainhouse J, Blackburn AC. Long-term stabilization of metastatic melanoma with sodium dichloroacetate. World J Clin Oncol 2017; 8(4): 371-377
Received
2017-02-08 11:09
Peer-Review Started
2017-02-12 21:53
To Make the First Decision
2017-03-27 11:21
Return for Revision
2017-03-28 15:30
Revised
2017-04-12 11:39
Second Decision
2017-05-11 13:48
Accepted by Journal Editor-in-Chief
2017-05-11 23:16
Accepted by Company Editor-in-Chief
2017-05-31 02:46
Articles in Press
2017-05-31 02:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-03 03:48
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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