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5/31/2017 2:46:12 AM | Browse: 358 | Download: 205
Publication Name World Journal of Clinical Oncology
Manuscript ID 33274
Country of Manuscript Source Canada
Specialty Oncology
Manuscript Type Case Report
Article Title Long-term stabilization of metastatic melanoma with sodium dichloroacetate
Manuscript Source Invited Manuscript
All Author List Akbar Khan, Doug Andrews, Jill Shainhouse and Anneke C Blackburn
Funding Agency and Grant Number
Correspondence To Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc, 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan@medicorcancer.com
Keywords Dichloroacetate; Cancer; BRAF; Melanoma; Cytostatic
Core Tip Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007. It has been shown that DCA therapy can result in a classic response which is measured by reduction or disappearance of tumours on imaging. However, DCA can also halt cancer cell growth without causing apoptosis (cytostatic effect). This can result in long-term stabilization of metastatic cancer. We present a case of oral DCA therapy resulting in reduction and stabilization of metastatic melanoma in a 32-year-old male for over 4 years, with only minor side effects.
Citation Khan A, Andrews D, Shainhouse J, Blackburn AC. Long-term stabilization of metastatic melanoma with sodium dichloroacetate. World J Clin Oncol 2017; 8(4): 371-377
2017-02-08 11:09
Peer-Review Started
2017-02-12 21:53
To Make the First Decision
2017-03-27 11:21
Return for Revision
2017-03-28 15:30
2017-04-12 11:39
Second Decision
2017-05-11 13:48
Accepted by Journal Editor-in-Chief
2017-05-11 23:16
Accepted by Company Editor-in-Chief
2017-05-31 02:46
Articles in Press
2017-05-31 02:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-03 03:48
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 03086186
Editorial Director Xiu-Xia Song
Journal Chief Editor Godefridus J Peters
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Ya-Jing Lu (Quit in 2018)
Responsible Electronic Editor Ya-Jing Lu (Quit in 2018)
Responsible Science Editor Fang-Fang Ji
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJCO-8-371.pdf
Full Article (Word) WJCO-8-371.doc
Revised Manuscript 33274-Review.docx
Peer-review Report 33274-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33274-Journal editor-in-chief review report.pdf
Answering Reviewers 33274-Answering reviewers.pdf
Scientific Misconduct Check 33274-Scientific misconduct check.pdf
Scientific Editor Work List 33274-Scientific editor work list.pdf
Audio Core Tip 33274-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 33274-Conflict-of-interest statement.pdf
Copyright License Agreement 33274-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 33274-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 33274-Institutional review board statement.pdf