Publication Name	World Journal of Gastroenterology
Manuscript ID	33598
Country	Italy

Category	Surgery
Manuscript Type	Case Control Study
Article Title	Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series
Manuscript Source	Unsolicited Manuscript
All Author List	Sarah Molfino, Carla Baronchelli, Simone Giacopuzzi, Daniele Marrelli, Paolo Morgagni, Maria Bencivenga, Luca Saragoni, Carla Vindigni, Nazario Portolani, Maristella Botticini, Giovanni De Manzoni and Gian Luca Baiocchi
Funding Agency and Grant Number
Corresponding Author	Gian Luca Baiocchi, MD, Professor, Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, III Chirurgia Generale, Spedali Civili di Brescia, Brescia 25121, Italy. gianluca.baiocchi@unibs.it
Key Words	N0 gastric cancer; Recurrence; Prognostic factors; Pathological analysis; Lymphatic embolization; Perineural infiltration; p53; Ki67
Core Tip	We analyze the clinicopathological cha­racteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up in 4 Italian centers belonging to the Italian Research Group on Gastric Cancer between 1992 and 2010. Lymph node metastasis is the most important prognostic factor in patients undergoing radical surgery for gastric carcinoma. In-depth pathological analysis of two homogenous groups of pN0 patients, with and without recurrence during long-term follow-up, revealed two striking patterns: lymphatic embolization and perineural infiltration (two parameters that pathologists can easily report), and p53 and Ki67, represent significant factors for recurrence. The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up.
Citation	Baiocchi GL, Molfino S, Baronchelli C, Giacopuzzi S, Marrelli D, Morgagni P, Bencivenga M, Saragoni L, Vindigni C, Portolani N, Botticini M, De Manzoni G. Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series. World J Gastroenterol 2017; 23(45): 8000-8007

Received	2017-02-20 10:11
Peer-Review Started	2017-02-20 21:48
To Make the First Decision	2017-03-03 10:05
Return for Revision	2017-03-07 10:42
Revised	2017-09-19 15:23
Second Decision	2017-10-17 06:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-10-17 20:15
Articles in Press	2017-10-17 20:15
Publication Fee Transferred	2017-11-13 20:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-22 07:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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