Publication Name	World Journal of Gastroenterology
Manuscript ID	33656
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects of aspirin and enoxaparin in a rat model of liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Jie Li, Zhi-Hui Yang, Xiao-Liu Shi and De-Liang Liu
Funding Agency and Grant Number
Corresponding Author	Chen-Jie Li, MD, PhD, Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China. chenjielimao@126.com
Key Words	Aspirin; Enoxaparin; Thioacetamide; Liver fibrosis; Rat
Core Tip	Several evidences show that intrahepatic thrombosis is associated with liver fibrosis.Based on these observations, we hypothesize that routine use of antithrombotic drugs may prevent liver fibrosis. In our study, we successfully established a rat model of liver fibrosis after 8 weeks and successfully established a rat model of liver cirrhosis after 12 weeks through thioacetamide - induced method. Our study clearly shows that aspirin and enoxaparin can reduce liver fibrosis in rats. However, reporting the results in humans is more complicated,because we should consider other aspects as the renal function.
Citation	Li CJ, Yang ZH, Shi XL, Liu DL. Effects of aspirin and enoxaparin in a rat model of liver fibrosis. World J Gastroenterol 2017; 23(35): 6412-6419

Received	2017-02-23 08:49
Peer-Review Started	2017-02-24 17:19
To Make the First Decision	2017-06-05 00:29
Return for Revision	2017-06-10 11:54
Revised	2017-06-21 17:26
Second Decision	2017-08-07 05:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-08-15 15:23
Articles in Press	2017-08-15 15:23
Publication Fee Transferred	2017-08-18 04:48
Edit the Manuscript by Language Editor	2017-08-31 03:26
Typeset the Manuscript	2017-09-09 08:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com