BPG is committed to discovery and dissemination of knowledge
Articles in Press
6/19/2017 9:41:12 AM | Browse: 316 | Download: 176
Publication Name World Journal of Gastroenterology
Manuscript ID 33759
Country/Territory Singapore
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Current research and treatment for gastrointestinal stromal tumors
Manuscript Source Invited Manuscript
All Author List Kheng Tian Lim and Kok Yang Tan
Funding Agency and Grant Number
Corresponding Author Kheng Tian Lim, Department of Surgery, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Singapore. lim.kheng.tian@alexandrahealth.com.sg
Key Words Gastrointestinal stromal tumors; KIT gene; Platelet-derived growth factor receptor alpha gene; BRAF gene; Succinate dehydrogenase gene; CD117; Tyrosine kinase inhibitor; Molecular targeted therapy
Core Tip Research in the histogenesis of gastrointestinal stromal tumors (GISTs) identified gene mutations in KIT, platelet-derived growth factor receptor alpha and BRAF. The discovery of tyrosine kinase inhibitors (TKIs) has allowed targeted therapy in metastatic and high-risk resected GISTs. However, the emergence of TKI-resistant GISTs has raised some important treatment issues. Newer TKIs and alternative targeted therapy within the domain of BRAF and the mitogen-activated protein kinase signaling pathway, heat shock protein 90 and succinate dehydrogenase inhibition are being investigated and appear promising. Many clinical trials have been undertaken and are still ongoing to define the best molecular targeted therapy for GISTs. The European, American and Asian guidelines on GISTs provide useful resources for specialists dealing with these interesting tumors.
Citation Lim KT, Tan KY. Current research and treatment for gastrointestinal stromal tumors. World J Gastroenterol 2017; 23(27): 4856-4866
Received
2017-03-01 09:08
Peer-Review Started
2017-03-02 09:08
To Make the First Decision
2017-04-21 10:35
Return for Revision
2017-04-28 17:12
Revised
2017-05-11 16:59
Second Decision
2017-06-16 13:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-19 09:41
Articles in Press
2017-06-19 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-06-23 20:37
Typeset the Manuscript
2017-07-14 04:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com