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Publication Name World Journal of Hepatology
Manuscript ID 33773
Country/Territory Brazil
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Innate lymphoid cells in tissue homeostasis and diseases
Manuscript Source Invited Manuscript
All Author List Aline Ignacio, Cristiane Naffah Souza Breda and Niels Olsen Saraiva Camara
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2012/02270-2
Corresponding Author Niels Olsen Saraiva Camara, MD, PhD, Professor, Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, Department of Immunology, University of São Paulo, Av. Prof. Lineu Prestes, 1730, Cidade Universitária, São Paulo, SP 05508-900, Brazil. niels@icb.usp.br
Key Words Innate lymphoid cells; Intestine; Liver; Homeostasis; Inflammatory diseases
Core Tip Receiving approximately 70% of blood through the portal vein, the liver represents one of the most important sites of defense against invading pathogens. In addition, the liver and the intestine are important immune organs, as they are often in contact with antigens and endotoxins produced by the gut microbiota. These organs are densely populated by innate immune cells such as natural killer cells, dendritic cells, macrophages, natural killer T cells and innate lymphoid cells (ILCs), which are rapidly activated by commensal and pathogenic antigens, growth factors, cytokines and host metabolites. Recent studies have been focused on discovering the role of ILCs and how these cell populations can regulate the immune response. Our goal is to discuss innovative literature highlighting the importance of ILCs in the context of infectious disease, tissue repair, tolerance of gut microbiota and inflammatory diseases that affect the liver and intestine homeostasis.
Citation Ignacio A, Breda CNS, Camara NOS. Innate lymphoid cells in tissue homeostasis and diseases. World J Hepatol 2017; 9(23): 979-989
Received
2017-03-01 08:20
Peer-Review Started
2017-03-02 16:35
To Make the First Decision
2017-03-27 11:26
Return for Revision
2017-03-28 16:05
Revised
2017-04-24 09:58
Second Decision
2017-06-02 00:25
Accepted by Journal Editor-in-Chief
2017-06-02 01:35
Accepted by Company Editor-in-Chief
2017-06-20 02:03
Articles in Press
2017-06-20 02:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-14 07:59
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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