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Publication Name World Journal of Orthopedics
Manuscript ID 33884
Country/Territory Finland
Category Orthopedics
Manuscript Type Retrospective Study
Article Title Total joint replacement in inhibitor-positive haemophilia: Long-term outcome analysis in fifteen patients
Manuscript Source Unsolicited Manuscript
All Author List Heidi Danielson, Riitta Lassila, Pekka Ylinen and Timo Yrjönen
Funding Agency and Grant Number
Corresponding Author Timo Yrjönen, MD, PhD, Orton Orthopaedic Hospital, Invalid Foundation, Tenholantie 10, Helsinki 00280, Finland. timo.yrjonen@orton.fi
Key Words Haemophilia; Joint replacement; Inhibitor; Cost analysis; Arthroplasty
Core Tip There are only few reports including joint arthroplasties on inhibitor-positive haemophilia patients. Generally the focus is mainly on immediate haemostatic outcome leaving the long-term orthopaedic results unreported. Our study brings out the importance of long-term and overall outcome when performing elective life-quality surgery. Management of inhibitor patients is especially challenging regarding not only the operative treatment but also the costs. As the health economic analysis of the topic is lacking, we provide new data. According to our cost analysis, preoperative immune-tolerance induction for high responder patients will bring cost- and outcome benefit both in surgery and preventing postoperative bleeds.
Citation Danielson H, Lassila R, Ylinen P, Yrjönen T. Total joint replacement in inhibitor-positive haemophilia: Long-term outcome analysis in fifteen patients. World J Orthop 2017; 8(10): 777-784
Received
2017-03-15 10:38
Peer-Review Started
2017-03-17 09:36
To Make the First Decision
2017-07-10 00:34
Return for Revision
2017-07-11 02:17
Revised
2017-07-22 21:11
Second Decision
2017-08-10 03:39
Accepted by Journal Editor-in-Chief
2017-08-10 21:12
Accepted by Company Editor-in-Chief
2017-08-16 02:36
Articles in Press
2017-08-16 02:36
Publication Fee Transferred
2017-09-01 08:57
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-21 03:00
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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