Publication Name	World Journal of Cardiology
Manuscript ID	34049
Country	Denmark

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Transposition of the great arteries - a phenotype associated with 16p11.2 duplications?
Manuscript Source	Unsolicited Manuscript
All Author List	Zarmiga Karunanithi, Else Marie Vestergaard and Mette H Lauridsen
Funding Agency and Grant Number	Funding Agency Grant Number Helga and Peter Kornings Fund
Corresponding Author	Mette H Lauridsen, MD, Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark. lauridsen.mette@auh.rm.dk
Key Words	Transposition of the great arteries; Copy number variation; Genetics; 16p11.2; Microduplication
Core Tip	Rare copy number variations may be of significance to the aetiology of transposition of the great arteries. This paper reports, for the first time, the finding of a 16p11.2 microduplication in a patient with transposition of the great arteries. Recognizing a possible genetic association to transposition of the great arteries will spur investigations into associated phenotypic effects such as developmental delays, thus allowing for earlier identification and treatment. We recommend that chromosomal microarray be considered part of the diagnostic work-up in patients with transposition of the great arteries.
Citation	Karunanithi Z, Vestergaard EM, Lauridsen MH. Transposition of the great arteries - a phenotype associated with 16p11.2 duplications? World J Cardiol 2017; 9(12): 848-852

Received	2017-03-24 09:10
Peer-Review Started	2017-03-24 17:15
To Make the First Decision	2017-07-10 00:50
Return for Revision	2017-07-17 09:15
Revised	2017-08-21 08:14
Second Decision	2017-09-08 01:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-13 20:03
Articles in Press	2017-09-13 20:03
Publication Fee Transferred	2017-10-27 02:59
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-19 08:30

ISSN	1949-8462 (online)
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