Publication Name	World Journal of Gastroenterology
Manuscript ID	34061
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion
Manuscript Source	Unsolicited Manuscript
All Author List	Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai and Masayoshi Takeuchi
Funding Agency and Grant Number	Funding Agency Grant Number Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 25282029 Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 26750056 Grants from Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 16H01811
Corresponding Author	Takanobu Takata, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan. takajjjj@kanazawa-med.ac.jp
Key Words	Tumor promotion; Glyceraldehyde-derived advanced glycation-end products; Pancreatic ductal adenocarcinoma
Core Tip	The mechanisms promoting pancreatic ductal adenocarcinoma (PDAC) in the pancreas of Type 2 diabetes mellitus patients have not yet been elucidated. We hypothesized that glyceraldehyde (GA)-derived advanced glycation-end products (GA-AGEs) promote PDAC. PANC-1 cells were treated with GA, which induced the production of intracellular GA-AGEs and cell death. The high-molecular-weight complexes of heat shock proteins were produced after GA treatment in a dose-dependent manner. GA-AGEs-bovine serum albumin promoted the proliferation of PANC-1 cells. Although intracellular GA-AGEs induce pancreatic cancer cell death, their secretion and release may promote the proliferation of other pancreatic cancer cells.
Citation	Takata T, Ueda T, Sakasai-Sakai A, Takeuchi M. Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion. World J Gastroenterol 2017; 23(27): 4910-4919

Received	2017-04-05 11:30
Peer-Review Started	2017-04-10 08:24
To Make the First Decision	2017-04-26 08:54
Return for Revision	2017-04-28 17:22
Revised	2017-05-10 18:19
Second Decision	2017-06-16 13:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-06-19 09:45
Articles in Press	2017-06-19 09:45
Publication Fee Transferred	2017-06-22 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-14 02:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com