Publication Name	World Journal of Gastroenterology
Manuscript ID	34076
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Tenofovir vs lamivudine plus adefovir in chronic hepatitis B: TENOSIMP-B study
Manuscript Source	Unsolicited Manuscript
All Author List	Manuel Rodríguez, Juan Manuel Pascasio, Enrique Fraga, Javier Fuentes, Martín Prieto, Gloria Sánchez, José Luis Calleja, Esther Molina, María Luisa García-Buey, Maria Ángeles Blanco, Javier Salmerón, María Lucia Bonet, José Antonio Pons, José Manuel González, Miguel Ángel Casado, Francisco Jorquera and the TENOSIMP-B Research Group
Funding Agency and Grant Number	Funding Agency Grant Number Gilead Sciences SL collaborated in the unconditional funding of the TENOSIMP-B study
Corresponding Author	Manuel Rodríguez, MD, Liver Unit, Division of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain. amunoz@porib.com
Key Words	Hepatitis B; Tenofovir; Lamivudine+Adefovir; Efficacy; Safety; Adherence; Costs
Core Tip	The Tenosimp-B study was performed to demonstrate the non-inferiority (15% non-inferiority limit) of tenofovir disoproxil fumarate (TDF) monotherapy versus the combination of lamivudine+adefovir (LAM+ADF) in 46 patients with chronic hepatitis B (CHB) and resistance to LAM (22 with TDF and 24 with LAM+ADV). TDF demonstrated its safety (no significant differences in adverse events (AEs), kidney function or liver function) and non-inferiority in maintaining virologic response (undetectable hepatitis B virus DNA [HBV-DNA] and negative for hepatitis B e antigen [HBeAg]) during the study, without differences in adherence to treatment. Additionally, the use of TDF resulted in significant savings in hospital costs.
Citation	Rodríguez M, Pascasio JM, Fraga E, Fuentes J, Prieto M, Sánchez-Antolín G, Calleja JL, Molina E, García-Buey ML, Blanco MÁ, Salmerón J, Bonet ML, Pons JA, González JM, Casado MÁ, Jorquera F, Group TTBR. Tenofovir vs lamivudine plus adefovir in chronic hepatitis B: TENOSIMP-B study. World J Gastroenterol 2017; 23(41): 7459-7469

Received	2017-03-25 15:16
Peer-Review Started	2017-03-29 15:31
To Make the First Decision	2017-04-20 13:53
Return for Revision	2017-04-20 16:38
Revised	2017-05-22 01:47
Second Decision	2017-06-16 13:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-06-19 09:45
Articles in Press	2017-06-19 09:45
Publication Fee Transferred	2017-10-09 06:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-24 09:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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