BPG is committed to discovery and dissemination of knowledge
Articles in Press
9/13/2017 7:31:01 PM | Browse: 63 | Download: 120
Publication Name World Journal of Stem Cells
Manuscript ID 34298
Country of Manuscript Source Japan
Specialty Cell Biology
Manuscript Type Basic Study
Article Title Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential
Manuscript Source Unsolicited Manuscript
All Author List Harumichi Itoh, Shimpei Nishikawa, Tomoya Haraguchi, Yu Arikawa, Shotaro Eto, Masato Hiyama, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yusuke Sakai, Kenji Tani, Yasuho Taura and Kazuhito Itamoto
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS KAKENHI (Grants-in-Aid for Scientific Research; grant No. 26893172) to Nishikawa S
Correspondence To Shimpei Nishikawa, PhD, Department of Small Animal Clinical Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan. sn2007@yamaguchi-u.ac.jp
Keywords Adipose-derived stem/stromal cell; Aldehyde dehydrogenase activity; Flow cytometry; Subpopulation; Ribosome
Core Tip Aldehyde dehydrogenase (ALDH) activity is widely used as a stem cell marker in several types of normal or malignant tissues. However, there was no report of ALDH activity in murine adipose-derived stem cells (ADSCs). Here, our study demonstrated a subpopulation defined by high ALDH activity within murine ADSCs. The subpopulation with high ALDH activity (ALDHHi) showed enhanced differentiation potentials into adipocyte and osteocyte. Furthermore, gene set enrichment analysis revealed that ribosome-related gene sets were enriched in ALDHHi of murine ADSCs. We showed relationship between ALDHHi and ribosome biosynthesis, providing a novel insight of mesenchymal stem cell biology.
Citation Itoh H, Nishikawa S, Haraguchi T, Arikawa Y, Eto S, Hiyama M, Iseri T, Itoh Y, Nakaichi M, Sakai Y, Tani K, Taura Y, Itamoto K. Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential. World J Stem Cells 2017; 9(10): 179-186
Received
2017-04-24 09:35
Peer-Review Started
2017-04-26 08:37
To Make the First Decision
2017-05-23 00:47
Return for Revision
2017-05-23 09:30
Revised
2017-07-11 00:34
Second Decision
2017-09-06 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-13 19:31
Articles in Press
2017-09-13 19:31
Publication Fee Transferred
2017-10-04 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-23 07:18
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 00609371, 03478635, 02446280, 00504800, 01554116, 02445899, 01851506, and 01047169
Editorial Director Xiu-Xia Song
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor Ya-Jing Lu
Responsible Electronic Editor Ya-Jing Lu
Responsible Science Editor Li-Jun Cui
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJSC-9-179.pdf
Full Article (Word) WJSC-9-179.doc
Revised Manuscript 34298-Review.docx
Peer-review Report 34298-Peer-review(s).pdf
Answering Reviewers 34298-Answering reviewers.pdf
Scientific Misconduct Check 34298-Scientific misconduct check.pdf
Scientific Editor Work List 34298-Scientific editor work list.pdf
Audio Core Tip 34298-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 34298-Conflict-of-interest statement.pdf
Copyright License Agreement 34298-Copyright assignment.pdf
Data Sharing Statement 34298-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34298-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 34298-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 34298-Institutional review board statement.pdf
Scientific Research Process 34298-Scientific research process.pdf