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Publication Name World Journal of Gastroenterology
Manuscript ID 34743
Country of Manuscript Source Sweden
Specialty Physiology
Manuscript Type Basic Study
Article Title Induction of precocious intestinal maturation in T-cell deficient athymic neonatal rats
Manuscript Source Unsolicited Manuscript
All Author List Ester Arévalo Sureda, Catherine Gidlund, Björn Weström and Olena Prykhodko
Funding Agency and Grant Number
Funding Agency Grant Number
Director Albert Påhlssons Foundation in Malmö, Sweden
Royal Physiographic Society in Lund, Sweden
Correspondence To Ester Arévalo Sureda, PhD, Department of Biology, Lund University, Sölvegatan 35C, Lund 22362, Sweden. ester.arevalo_sureda@biol.lu.se
Keywords Gut; Intestinal permeability; Passive immunity; Pancreas; Immunoglobulin G
Core Tip The rat is born with an immature gut and is thus a suitable model to study gut development. Enteral provocation with phytohaemagglutinin or protease induces precocious gut maturation in conventional (euthymic) rats. It has been suggested that T-lymphocytes are required for gut digestive maturation. The current study showed that precocious gut maturation could be induced by enteral provocation in athymic nude rats similar to that which occurs in euthymic rats. The few intestinal mucosal CD3+-T-cells that were observed in the athymic nude rats appeared to be unaffected by enteral provocation. The intestinal absorptive capacity in nude pups was enhanced when nurtured by conventional (immunocompetent) foster dams.
Citation Arévalo Sureda E, Gidlund C, Weström B, Prykhodko O. Induction of precocious intestinal maturation in T-cell deficient athymic neonatal rats. World J Gastroenterol 2017; 23(42): 7531-7540
Received
2017-05-24 01:24
Peer-Review Started
2017-05-24 13:14
To Make the First Decision
2017-07-13 05:38
Return for Revision
2017-07-17 06:44
Revised
2017-07-31 14:29
Second Decision
2017-09-06 23:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-13 03:11
Articles in Press
2017-09-13 03:11
Publication Fee Transferred
2017-10-12 03:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-11-06 04:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Yuan Qi
Reviewer Code 00503062, and 00502973
Editorial Director Yuan Qi
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-23-7531.pdf
Full Article (Word) WJG-23-7531.doc
Revised Manuscript 34743-Review.docx
Peer-review Report 34743-Peer-review(s).pdf
Answering Reviewers 34743-Answering reviewers.pdf
Scientific Misconduct Check 34743-Scientific misconduct check.pdf
Scientific Editor Work List 34743-Scientific editor work list.pdf
Audio Core Tip 34743-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 34743-Conflict-of-interest statement.pdf
Copyright License Agreement 34743-Copyright assignment.pdf
Data Sharing Statement 34743-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34743-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 34743-Institutional animal care and use committee statement.pdf
Scientific Research Process 34743-Scientific research process.pdf