Publication Name	World Journal of Gastroenterology
Manuscript ID	35444
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Chun Jing, Jun Zhang, Chen Feng, Yuan-Yuan Nian, Jin-Hai Wang, Hao Hu, Bao-De Yang, Xiao-Ming Sun, Jian-Yun Zheng and Xiao-Ran Yin
Funding Agency and Grant Number
Corresponding Author	Jun Zhang, PhD, Chief Doctor, Professor, Department of Gastroenterology, Second Hospital Affiliated to the Medical School of Xi’an Jiao Tong University, No. 157, West Road 5, Xi’an 710004, Shaanxi Province, China. jun3z@163.com
Key Words	Gastric hypersensitivity; Anxiety; Functional dyspepsia; 5-Hydroxytryptamine; γ-aminobutyric acid; Brain-derived neurotrophic factor; Nesfatin-1; Rat model
Core Tip	Functional dyspepsia (FD) is a common gastrointestinal disorder in clinic. Gastric hypersensitivity (GHS) and anxiety are important factors triggering or aggravating it, however, the mechanisms by which affect the development of FD are still unknown. In part, this is due to a lack of suitable animal models of FD with anxiety and GHS. Our study provided such a newly developed rat model induced by sequential stress. It demonstrated the complex behavioral characteristics of anxiety and GHS, and the complicated alterations in some anxiety-related neurobiochemical modulators such as 5-HT, GABA, BDNF and nesfatin-1 in the hippocampus, plasma and gastric fundus.
Citation	Jing FC, Zhang J, Feng C, Nian YY, Wang JH, Hu H, Yang BD, Sun XM, Zheng JY, Yin XR. Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress. World J Gastroenterol 2017; 23(42): 7594-7608

Received	2017-07-28 02:00
Peer-Review Started	2017-07-28 02:29
To Make the First Decision	2017-09-27 00:42
Return for Revision	2017-09-27 05:48
Revised	2017-10-04 02:09
Second Decision	2017-10-17 07:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-10-18 03:45
Articles in Press	2017-10-18 03:45
Publication Fee Transferred	2017-10-19 10:22
Edit the Manuscript by Language Editor	2017-10-23 13:45
Typeset the Manuscript	2017-11-10 06:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com