Publication Name	World Journal of Gastroenterology
Manuscript ID	35624
Country	France

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Stricturing Crohn’s disease-like colitis in a patient treated with belatacept
Manuscript Source	Unsolicited Manuscript
All Author List	Anne Bozon, Guillaume Jeantet, Benjamin Rivière, Natalie Funakoshi, Gaspard Dufour, Roman Combes, Jean-Christophe Valats, Sylvie Delmas, Jean emmanuel Serre, Michael Bismuth, Jeanne Ramos, Moglie Le Quintrec, Pierre Blanc and Guillaume Pineton de Chambrun
Funding Agency and Grant Number
Corresponding Author	Guillaume Pineton de Chambrun, MD, PhD, Assistant Professor, Department of Gastroenterology, Saint-Eloi Hospital, Montpellier University Hospital, 80 avenue Augustin Fliche, Montpellier 34000, France. gpinetondechambrun@yahoo.fr
Key Words	Inflammatory bowel disease; Crohn’s disease; Colitis; Belatacept; HHV-6
Core Tip	Belatacept is a cytotoxic T-lymphocyte-associated antigen 4 Ig fusion protein used for kidney transplant rejection prophylaxis. We report the appearance of a severe stricturing Crohn’s disease-like colitis in a patient who was treated with belatacept. After belatacept withdrawal, complete mucosal healing was observed with the persistence of a non-ulcerated left-sided colonic stricture which did not allow passage of the colonoscope. So, in patients treated with belatacept who develop digestive symptoms such as diarrhea or intestinal bleeding, we recommend performing early colonoscopy and considering belatacept withdrawal in case of suggestive endoscopic and histologic findings in order to avoid colonic sequela.
Citation	Bozon A, Jeantet G, Rivière B, Funakoshi N, Dufour G, Combes R, Valats JC, Delmas S, Serre JE, Bismuth M, Ramos J, Le Quintrec M, Blanc P, Pineton de Chambrun G. Stricturing Crohn’s disease-like colitis in a patient treated with belatacept. World J Gastroenterol 2017; 23(48): 8660-8665

Received	2017-07-28 09:30
Peer-Review Started	2017-07-28 18:07
To Make the First Decision	2017-08-30 04:12
Return for Revision	2017-09-01 19:36
Revised	2017-09-15 21:34
Second Decision	2017-10-11 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-10-17 20:12
Articles in Press	2017-10-17 20:12
Publication Fee Transferred	2017-11-02 11:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-09 13:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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