Publication Name	World Journal of Stem Cells
Manuscript ID	35695
Country	United States

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Yin and Yang of mesenchymal stem cells and aplastic anemia
Manuscript Source	Unsolicited Manuscript
All Author List	Larisa Broglie, David Margolis and Jeffrey A Medin
Funding Agency and Grant Number	Funding Agency Grant Number National Center for Advancing Translational Sciences, National Institutes of Health 1TL1TR001437 (to Broglie L) National Center for Advancing Translational Sciences, National Institutes of Health UL1TR001436 (to Broglie L) MACC Fund to Margolis D and Medin JA
Corresponding Author	Larisa Broglie, MD, Academic Fellow, Departments of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, MFRC 3018, Milwaukee, WI 53202, United States. lbroglie@mcw.edu
Key Words	Hematopoiesis; Targeted therapies; Stem cells; Hematopoietic stem cell transplantation; Aplastic anemia; Mesenchymal stem cells
Core Tip	Acquired aplastic anemia (AA) is a bone marrow failure syndrome characterized by peripheral cytopenia and bone marrow hypoplasia and is ultimately fatal without treatment. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Here we review the current understanding of the pathogenesis of AA and the function of mesenchymal stem cells (MSCs), and suggest that MSCs should be a target for further trials in AA.
Citation	Broglie L, Margolis D, Medin JA. Yin and Yang of mesenchymal stem cells and aplastic anemia. World J Stem Cells 2017; 9(12): 219-226

Received	2017-08-02 02:10
Peer-Review Started	2017-08-03 06:33
To Make the First Decision	2017-09-04 00:45
Return for Revision	2017-09-04 03:06
Revised	2017-09-14 16:38
Second Decision	2017-09-27 05:56
Accepted by Journal Editor-in-Chief	2017-09-27 12:52
Accepted by Company Editor-in-Chief	2017-10-17 22:50
Articles in Press	2017-10-17 22:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-19 08:35

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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