Publication Name	World Journal of Gastroenterology
Manuscript ID	35930
Country	China

Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Ying Wang, Ping Tao, Hong-Yi Hu, Jian-Ye Yuan, Lei Zhao, Bo-Yun Sun, Wan-Jun Zhang and Jiang Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81373616
Corresponding Author	Jiang Lin, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Shanghai 200032, China. linjiang@longhua.net
Key Words	Microvascular injury; Panax notoginseng; Ulcerative colitis; Oxidative stress
Core Tip	Panax notoginseng (PN) is a traditional Chinese medicine used to treat ulcerative colitis, but its mechanisms are unclear. In our study, we found that PN promoted repair of injuries of colonic mucosa and microvessels in rat colitis. PN decreased concentrations of vascular endothelial growth factor, interleukin (IL)-6 and tumor necrosis factor-α while it increased the concentrations of IL-4 and IL-10 in serum. It also decreased concentrations of myeloperoxidase and hypoxia-inducible factor-1α while it increased the concentration of superoxide dismutase in colon. So it is concluded that PN repairs mucosal and vascular injuries in rat colitis via attenuating inflammation and oxidative stress in the colonic mucosa.
Citation	Wang SY, Tao P, Hu HY, Yuan JY, Zhao L, Sun BY, Zhang WJ, Lin J. Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis. World J Gastroenterol 2017; 23(47): 8308-8320

Received	2017-09-06 03:04
Peer-Review Started	2017-09-07 01:07
To Make the First Decision	2017-10-11 01:00
Return for Revision	2017-10-11 10:10
Revised	2017-11-03 12:02
Second Decision	2017-11-14 06:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-14 19:03
Articles in Press	2017-11-14 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-11-19 15:24
Typeset the Manuscript	2017-12-04 08:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com